| 诱发肺结核动物模型方法及评价 |
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| 引用本文： | 张丹参,张健美. 诱发肺结核动物模型方法及评价[J]. 神经药理学报, 2019, 9(6): 11-14. DOI: 10.3969/j.issn.2095-1396.2019.06.003 |
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| 作者姓名： | 张丹参 张健美 |
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| 作者单位： | 河北科技大学，石家庄，050018，中国 |
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| 基金项目： | 河北省自然科学基金项目（No.H2016208058），河北省高等学校科学技术研究项目（No.ZD2016009） |
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| 摘 要： | 结核病是威胁全球人类健康的重要人畜共患病,结核病由结核分枝杆菌(mycobacterium tuberculosis,MTB)感染引起,可累及全身并引发肺部感染,为最常见的呼吸系统疾病。结核病动物模型用于四个基本目的:阐明病原体的毒力策略;确定天然和疫苗诱导抗性的机制;筛选新型抗结核药物候选药物;并筛选新型疫苗。一些模型提供了非常详细地操纵和监测免疫系统的能力(如小鼠),而其他模型更忠实地再现了人类肺结核(tuberculosis,TB)发病机理的特定方面。
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| 关 键 词： | 肺结核 动物模型 方法评价 |
Methods and Evaluation of Animal Models of Induced Pulmonary Tuberculosis |
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| ZHANG Dan-shen,ZHANG Jian-mei. Methods and Evaluation of Animal Models of Induced Pulmonary Tuberculosis[J]. Journal of Hebei North University(Medical Edition), 2019, 9(6): 11-14. DOI: 10.3969/j.issn.2095-1396.2019.06.003 |
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| Authors: | ZHANG Dan-shen ZHANG Jian-mei |
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| Affiliation: | Hebei University of Science and Technology，Shijiazhuang，050018，China |
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| Abstract: | Tuberculosis is an important zoonotic disease that threatens global human health. Tuberculosis is caused by infection with mycobacterium tuberculosis（MTB），which can affect the body and cause lung infections. It is the most common respiratory disease. The animal model of tuberculosis is used for four basic purposes：to elucidate the virulence strategies of pathogens；to determine the mechanisms by which natural and vaccine-induced resistance；to screen for new anti-tuberculosis drug candidates；and to screen for novel vaccines. Some models provide the ability to manipulate and monitor the immune system in great detail（eg，mice），while other models more faithfully reproduce specific aspects of the pathogenesis of human TB. |
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| Keywords: | tuberculosis animal model method evaluation |
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