两种软件在测量先天性小眼球眼眶容积中的临床研究

目的评估两种软件测量先天性小眼球患者眼眶容积的准确性。 方法横断面回顾性研究。纳入2007年1月至2019年1月就诊于北京同仁医院眼科中心的先天性小眼球患者86例(86只眼)作为研究对象。其中,男性47例(47只眼),女性39例(39只眼);年龄1~57岁,平均年龄(10.0±11.1)岁。根据患者年龄和发育情况,分为A~I组共9组。全部患者行眼眶CT检查,分别使用iPlan Cranial 2.5软件和Syngo MMWPVE 36A软件进行眼眶三维重建并测量眼眶容积。眼眶容积以均数±标准差描述。采用Bland-altman图评估两种软件测量的一致性;采用组内相关系数(ICC)分别评估患侧、健侧眼眶测量的一致性;计算眼眶容积患侧/健侧比值,并描绘年龄-比值曲线。 结果全部86例(86只眼)患者,iPlan Cranial软件和Syngo MMWP软件测量的患侧眼眶容积分别为(14.51±3.53)cm³和(14.10±3.63)cm³;健侧分别为(17.70±3.53)cm³和(17.40±3.60)cm³。iPlanCranial软件测量A~I组患者患侧的眼眶容积分别为(11.35±2.97)cm³、(13.33±2.59)cm³、(13.76±2.66)cm³、(13.82±2.68)cm³、(15.77±1.93)cm³、(15.52±1.15)cm³、(16.85±2.81)cm³、(15.85±2.00)cm³及(17.47±2.16)cm³;Syngo MMWP软件测量A~I组患者患侧的眼眶容积分别为(10.80±2.37)cm³、(13.36±2.37)cm³、(13.92±1.89)cm³、(13.36±2.66)cm³、(15.59±1.16)cm³、(15.08±1.88)cm³、(16.25±4.52)cm³、(14.99±2.76)cm³及(17.01±2.72)cm³;者iPlan Cranial软件测量A~I组患健侧的眼眶容积分别为(14.44±3.13)cm³、(16.15±2.37)cm³、(15.93±2.83)cm³、(17.37±1.40)cm³、(18.50±1.62)cm³、(19.24±1.37)cm³、(20.33±2.28)cm³、(20.29±1.23)cm³及(20.62±1.73)cm³;SyngoMMWP软件测量A~I组患者健侧的眼眶容积分别为(13.84±2.72)cm³、(16.03±2.04)cm³、(16.59±1.63)cm³、(17.16±1.21)cm³、(18.39±1.38)cm³、(18.93±1.97)cm³、(20.22±4.00)cm³、(19.09±2.27)cm³及(20.30±2.29)cm³。两种软件测量均值为0.4 cm³,95%一致性区间为(-3.0 cm³,+3.7 cm³);患侧眼眶容积测量的信度良好,经检验有统计学意义(95%CI：ICC＝0.881,0.821~0.922;P<0.05);健侧眼眶容积测量的信度良好,经检验有统计学意义(95%CI：ICC＝0.886,0.830~0.924;P<0.05)。iPlan Cranial软件和Syngo MMWP软件测量眼眶容积的时间分别为30 min和5 min。 结论两种软件眼眶容积测量结果的一致性好,但需注意眶口与眶尖边界识别;Syngo MMWP软件因测量便捷更适合大批量测量。

Clinical study of two software in measuring the orbital volume of congenital microphthalmia

ObjectiveTo evaluate the accuracy of orbital volume in congenital microphthalmia using two software. MethodsA cross-sectional retrospective study. A total of 86 patients (86 eyes) who were diagnosed with congenital microphthalmia from January 2007 to January 2019 in Beijing Tongren Eye Center of Beijing Tongren Hospital affiated to Capital Medical University. Among them, there were 47 males (47 eyes) and 39 females (39 eyes) with the average age of (10.0±11.1) years-old. Patients were divided into 9 groups according to age, from group A to group I. iPlan Cranial 2.5 and SyngoMMWP VE36A software were used to measure the orbital volume using orbital CT scan, and the orbital volume microphthalmic/contralateral ratio was calculated. Orbital volume was expressed as mean±standard deviation, Bland-altman and intraclass correlation coefficient (ICC) were used to evaluate the correlation and agreement between them. The microphthalmic/contralateral ratio was calculated and an age-ratio curve was plot. ResultsAmong of 86 patients (86 eyes), the affected orbital volume of iPlan Cranial software and Syngo MMWP software was (14.51±3.53) cm³ and (14.10±3.63) cm³, respectively; the unaffected orbital volume of iPlan Cranial software and Syngo MMWP software was (17.70±3.53) cm³ and (17.40±3.60) cm³, respectively. The affected orbital volume of the iPlan Cranial software in groups A to group I was (11.35±2.97) cm³, (13.33±2.59) cm³, (13.76±2.66) cm³, (13.82±2.68) cm³, (15.77±1.93) cm³, (15.52±1.15) cm³, (16.85±2.81) cm³, (15.85±2.00) cm³ and (17.47±2.16) cm³, respectively. The affected orbital volume of the Syngo MMWP software in groups A to group I was (10.80±2.37) cm³, (13.36±2.37) cm³, (13.92±1.89) cm³, (13.36±2.66) cm³, (15.59±1.16) cm³, (15.08±1.88) cm³, (16.25±4.52) cm³, (14.99±2.76) cm³ and (17.01±2.72) cm³, respectively. The unaffected orbital volume of the iPlan Cranial software in groups A to group I was (14.44±3.13) cm³, (16.15±2.37) cm³, (15.93±2.83) cm³, (17.37±1.40) cm³, (18.50±1.62) cm³, (19.24±1.37) cm³, (20.33±2.28) cm³, (20.29±1.23) cm³ and (20.62±1.73) cm³, respectively. The unaffected orbital volume of the Syngo MMWP software in groups A to group I was (13.84±2.72) cm³, (16.03±2.04) cm³, (16.59±1.63) cm³, (17.16±1.21) cm³, (18.39±1.38) cm³, (18.93±1.97) cm³, (20.22±4.00) cm³, (19.09±2.27) cm³ and (20.30±2.29) cm³, respectively. The mean between two software was 0.4 cm³; 95% limits of agreement (95%CI) was (-3.0 cm³, + 3.7 cm³). ICC of the affected orbital volume and the unaffected orbital volume was 0.881 (95%CI: 0.821 to 0.922; P<0.05) and 0.886 (95%CI: 0.830 to 0.924; P<0.05), respectively. The measurement time of iPlan Cranial software and Syngo MMWP software was 30 minutes and 5 minutes, respectively. ConclusionsThe orbital volume measurement between two software was excellent correlation, but the orbital rim and orbital apex boundary need to be rectified. The Syngo MMWP software was more suitable for mass measurement because of its simple and fast measurement.