利拉鲁肽联合胰岛素泵对2型糖尿病伴代谢综合征患者代谢指标的影响

目的探讨利拉鲁肽联合胰岛素泵对2型糖尿病（T2DM）伴代谢综合征（MetS）患者的临床疗效及代谢指标的影响。 方法选择2019年1月至2020年2月于江门市人民医院接受治疗的2型糖尿病伴MetS患者共60例，随机分为联合组和对照，其中联合组采用利拉鲁肽联合胰岛素泵治疗，对照组采用胰岛素泵治疗，比较两组患者的入院时及治疗2周、12周后的体质指标，以及血糖、糖化血红蛋白（HbA1c）及总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇（HDL-C）水平。 结果两组患者治疗前的平均BMI、腰围、血压水平对比差异无统计学意义（P>0.05），治疗12周联合组的BMI和腰围水平显著低于治疗前，且低于对照组（P<0.05），两组患者治疗前的空腹和餐后2h的血糖水平，C肽水平和HbA1c对比差异无统计学意义（P>0.05），联合组的C肽水平在治疗2周、12周时显著高于对照组（P<0.05），且联合组的HbA1c水平在治疗2周、12周时显著低于对照组（P<0.05），两组患者治疗前的平均TC、TG、LDL-C、HDL-C水平对比差异无统计学意义（P>0.05），联合组在干预2周时的TC、LDL-C水平及干预12周时的TC、TG、LDL-C水平均显著低于对照组，而HDL-C水平显著高于对照组，差异具有统计学意义（P<0.05）。 结论利拉鲁肽联合胰岛素泵可以有效改善T2DM合并MetS患者的体重，提高血糖控制效果，并改善血脂水平。

Impact of Lylalutide combined with insulin pump on metabolic indicators in patients with type 2 diabetes mellitus and metabolic syndrome

ObjectiveTo explore the effect of liraglutide combined with insulin pump on the clinical efficacy and metabolic indexes of patients with type 2 diabetes and metabolic syndrome. MethodsA total of 60 patients with type 2 diabetes and MetS treated in our hospital from January 2019 to February 2020 were selected and randomly divided into a combined group and a control group. The combined group was treated with liraglutide combined with insulin pump. The control group was treated with an insulin pump, and the BMI, waist circumference, blood pressure, blood glucose, glycated hemoglobin (HbA1c), and blood lipids (Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) were compared between the two groups at the time of admission and after 2 and 12 weeks of treatment. ResultsThere was no statistically significant difference in the average BMI, waist circumference and blood pressure before treatment between the two groups of patients (P>0.05). The BMI and waist circumference of the combined group after 12 weeks of treatment were significantly lower than before treatment and lower than the control group (P<0.05), the blood glucose level before treatment in both groups of patients, including fasting and 2h postprandial blood glucose levels, C peptide level and HbA1c difference was not statistically significant (P>0.05), the combination group C peptide level in treatment 2 Weeks and 12 weeks were significantly higher than the control group (P<0.05), and the HbA1c level of the combined group was significantly lower than the control group at 2 and 12 weeks of treatment (P<0.05). There was no significant difference in the average TC, TG, LDL-C, HDL-C levels between the two groups of patients before treatment (P>0.05). The levels of TC, TG and LDL-C were significantly lower than those of the control group, while the levels of HDL-C were significantly higher than that of the control group (P<0.05) . ConclusionsIn the perioperative period of weight loss and metabolic surgery, the implementation of rapid rehabilitation measures is superior to the traditional mode, which can significantly shorten the time of hospitalization, reduce postoperative complications, rapid recovery and save cost, and has outstanding application value.