LOXL1基因rs2165241位点多态性与剥脱综合征性青光眼易感性关系的Meta分析

目的探讨类赖氨酰氧化酶1（LOXL1）基因rs2165241位点多态性与剥脱综合征性青光眼（exfoliation syndrome，XFG）的发病风险的相关性。方法全面检索Web of science、Embase、PubMed、CNKI、万方数据库，查找关于LOXL1基因rs2165241位点多态性与XFG易感性关系的病例对照研究，检索时限为建库至2019年8月。由2名研究者根据纳入和排除标准提取相关资料后，运用Stata 10.0软件进行Meta分析。结果最终纳入19篇文献，19个研究，包括XFG组病人2422例，健康对照组3 549例，经异质性分析，提示各研究间有一定的异质性（P < 0.1），运用随机效应对数据进行Meta分析，结果显示，在总体人群之中，LOXL1基因rs2165241位点多态性与XFG存在一定易感性（TT vs.TC+CC:OR=3.87，95%CI=2.83~5.29，P < 0.01）。对总体数据进行亚组分析，结果显示:在亚洲人群中，LOXL1基因rs2165241位点多态性与XFG发病风险无统计学关联性（TT vs.TC+CC:OR=1.74，95%CI=0.58~5.17，P>0.05）；在高加索人群中，LOXL1基因rs2165241位点多态性可增加XFG的易感性（TT vs.TC+CC:OR=4.25，95%CI=3.07~5.88，P < 0.01）。结论LOXL1基因rs2165241位点多态性与XFG易感性相关，等位基因T可能与会增高患XFG的风险，特别是在高加索人群中。

Meta analysis of the relationship between polymorphism of LOXL1 gene RS2165241 and susceptibility of stripping syndrome glaucoma

ObjectiveTo investigate the association between the Lysyl oxidase like 1(LOXL1)gene polymorphism(rs2165241)and exfoliation syndrome glaucoma(XFG).MethodsThe Web of science, Embase, PubMed, CNKI and WanFang websites were searched to look for the association between the LOXL1 gene polymorphism(rs2165241)and XFG.The retrieval time was from the time of databases' establishment to August 2019.The relevant data were extracted by two researchers according to inclusion and exclusion criteria, and Meta analyzed using Stata 10.0 software.ResultsNineteen literatures and 19 studies were included, which was divided into the XFG group(2 422 cases)and healthy control group(3 549 cases).The results of heterogeneity analysis showed that there was some heterogeneity among studies(P < 0.1).The results of Meta analysis of random effects showed that the LOXL1 gene rs2165241 polymorphism was susceptible to XFG in the general population(TT vs.TC+CC:OR=3.87, 95%CI=2.83-5.29, P < 0.01).The results of subgroup analysis of the overall data showed that there was not statistical correlation between the polymorphism of LOXL1 gene rs2165241 and risk of XFG in Asian population(TT vs.TC+CC:OR=1.74, 95%CI=0.58-5.17, P>0.05), and the polymorphism of LOXL1 gene RS2165241 increased the susceptibility to XFG in Caucasian populations(TT vs.TC+CC:OR=4.25, 95%CI=3.07-5.88, P < 0.01).ConclusionsThe LOXL1 gene polymorphism(rs2165241)is associated with XFG susceptibility, and the allele T may increase the risk of XFG, especially in Caucasian populations.