低分子肝素钠联合地屈孕酮对先兆流产患者保胎成功率及妊娠结局的影响

目的探讨低分子肝素钠联合地屈孕酮对先兆流产患者保胎成功率及妊娠结局的影响。方法选择2016年2月—2018年12月本院收治的70例先兆流产患者,按随机数表法分为两组,每组35例。对照组口服地屈孕酮,观察组在此基础上注射低分子肝素钠,对比两组患者血常规和凝血指标、妊娠结局和保胎成功率。结果治疗后,观察组血小板(213.5±32.4)×109/L、纤维蛋白原(1.65±0.11)g/L和D-二聚体(3.68±0.24)μg/L水平低于对照组(233.5±33.1)×109/L、(1.81±0.13)g/L、(4.02±0.32)μg/L,早产率2.86%低于对照组22.86%,足月妊娠率94.28%高于对照组57.14%,差异有统计学意义(P<0.05)。结论先兆流产患者采用低分子肝素钠联合地屈孕酮有利于改善妊娠结局,提高保胎成功率,效果优于单一使用地屈孕酮。

Effect of low-molecular sodium heparin combined with dydrogesterone on success rate of pregnancy and outcome of pregnancy in patients with threatened abortion

Objective To explore the effect of low-molecular sodium heparin combined with dydrogesterone on the success rate of pregnancy and the outcome of pregnancy in patients with threatened abortion. Methods A total of 70 patients with threatened abortion from February 2016 to December 2018 were randomly divided into a control group and a trial group according to the random number table method. In the control group, dydrogesterone was taken orally, and in the trial group, low-molecular sodium heparin was injected on the basis of the treatment of the control group. The blood routine and coagulation indexes, the pregnancy outcomes, and the pregnancy rates of the two groups were investigated and the results were compared. Results After the treatment, the platelet , fibrinogen , and D-dimer of the trial group were lower than those of the control group . The rate of premature birth of the trial group was 2.86%, which was lower than that of the control group (22.86%). The full-term pregnancy rate of the trial group was 94.28%, which was higher than that of the control group (57.14%), and the difference was significant (P < 0.05). Conclusion The combination of low-molecular sodium heparin and dydrogesterone can improve the outcome of pregnancy and improve the success rate of the pregnancy, that is the combination of low-molecular sodium heparin and dydrogesterone is superior to the single use of dydrogesterone.