| N-甲基-D-天冬氨酸受体:治疗椎管内阿片类药物所致瘙痒的新方向 |
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| 引用本文： | 谭骁,申乐,黄宇光. N-甲基-D-天冬氨酸受体:治疗椎管内阿片类药物所致瘙痒的新方向[J]. 中国医学科学院学报, 2019, 41(6): 851-856. DOI: 10.3881/j.issn.1000-503X.11096 |
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| 作者姓名： | 谭骁 申乐 黄宇光 |
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| 作者单位： | 中国医学科学院 北京协和医学院 北京协和医院麻醉科,北京 100730 |
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| 基金项目： | 国家自然科学基金(81200869) |
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| 摘 要： | 椎管内阿片类药物是常用的麻醉镇痛方式之一,但瘙痒是该镇痛方式给患者带来的极大困扰,目前的治疗手段存在一定的局限性。本文通过综述椎管内阿片类药物所致瘙痒的治疗现状、基础研究进展(包括神经递质学、阿片受体学和信号通路学),结合本课题组关于N-甲基-D-天冬氨酸(NMDA)受体与椎管内阿片类药物所致瘙痒的相关研究,为治疗椎管内阿片类药物所致瘙痒提供新思路。NMDA受体在椎管内阿片类药物所致瘙痒中可能发挥重要作用,NMDA受体拮抗剂在治疗椎管内阿片类药物所致瘙痒中具有一定的优势。
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| 关 键 词： | 瘙痒 阿片类药物 N-甲基-D-天冬氨酸受体 |
| 收稿时间： | 2018-12-14 |
N-methyl-D-aspartate Receptor:Potential Role in TreatingNeuraxial Opioid Induced Pruritus |
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| Xiao TAN,Le SHEN,Yuguang HUANG. N-methyl-D-aspartate Receptor:Potential Role in TreatingNeuraxial Opioid Induced Pruritus[J]. Acta Academiae Medicinae Sinicae, 2019, 41(6): 851-856. DOI: 10.3881/j.issn.1000-503X.11096 |
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| Authors: | Xiao TAN Le SHEN Yuguang HUANG |
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| Affiliation: | Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China |
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| Abstract: | Neuraxial opioid administration is one of the most common methods of anesthesia and analgesia,while itching is the most troublesome adverse effect.The current treatments for neuraxial opioid-induced pruritus still have certain limitations.This article reviews the current treatments and basic scientific findings(including neurotransmitters,opioid receptors,and signaling pathways)of pruritus caused by neuraxial opioids.Based on our recent findings on N-methyl-D-aspartate(NMDA)receptors and pruritus caused by neuraxial opioids,we provide new ideas for the treatment of itching caused by neuraxial opioids.Since NMDA receptors may play a key role in neuraxial opioid-induced pruritus,NMDA receptor antagonists can have certain therapeutic advantages. |
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| Keywords: | itching opioids N-methyl-D-aspartate receptor |
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