Framingham风险评分与遗忘型轻度认知障碍的相关性

目的探讨Framingham风险评分与遗忘型轻度认知障碍（amnestic mild cognitive impairment, aMCI）的相关性，以期为阿尔茨海默症的早期预防提供有意义的临床依据。 方法选取2018年1月至2019年12月浙江医院收治的124老年人，均行神经心理学评估，其中aMCI老年人54例（aMCI组），认知正常老年人70例（正常组）。比较两组老年人的Framingham风险评分，并分析aMCI老年人Framingham风险评分与认知功能的相关性。计量资料的组间比较采用t检验或非参数Mann-Whitney U检验，计数资料的比较采用χ²检验，Framingham风险评分与认知功能的相关性采用Spearman相关分析。 结果两组对象一般资料（包括Framingham风险评分的组成指标）的差异无统计学意义（P>0.05）。aMCI组Framingham风险评分中位数为24%，四分位数间距为22%；正常组Framingham风险评分中位数为16.7%，四分位数间距为22%；差异有统计学意义（Z=-2.721，P<0.01）。aMCI老年人Framingham风险评分与简易智能状态检查量表及听觉词语学习测验20 min延迟回忆评分均呈显著负相关（r=-0.203、-0.570，P<0.01）。 结论Framingham风险评分与老年人认知功能有关，可作为老年人认知功能障碍的预警参考指标。

Correlation between Framingham risk score and amnestic mild cognitive impairment

ObjectiveTo explore the correlation between Framingham risk score and amnestic mild cognitive impairment (aMCI), in order to provide meaningful clinical basis for the early prevention of Alzheimer's disease. Methods124 elderly people admitted to Zhejiang Hospital from January 2018 to December 2019 were selected, including 54 elderly people with AMCI (AMCI group) and 70 elderly people with normal cognition (normal group). The Framingham risk score was compared between the two groups, and the correlation between the Framingham risk score and cognitive function in the elderly with AMCI was analyzed. T test was used to compare the normal distribution measurement data, the non-parametric Mann-Whitney U test was used to compare the phenanthrene normal distribution measurement data, and the χ² test was used to compare the counting data. Spearman correlation analysis was used to analyze the correlation between Framingham risk score and cognitive function. ResultsThere was no significant difference in general information including Framingham risk score components between the two groups (P > 0.05). The Framingham risk score was 24% (the interquartile spacing was 22%) in aMCI group and 16.7% (the interquartile spacing was 22%) in normal group, the difference between the two groups was statistically significant (Z=-2.721, P < 0.01). In aMCI group, the Framingham risk score was significantly negatively correlated with MMSE score and AVLT 20 min delayed recall score (r=-0.203, -0.570, P < 0.01). ConclusionFramingham risk score is related to the cognitive function of the elderly, which can be used as an early warning reference index of cognitive dysfunction in the elderly.