2型糖尿病病人血清尿酸与肌酐比值和颈动脉内膜-中层厚度的相关性分析

目的通过分析2型糖尿病病人血清尿酸与肌酐比值（SUA/SCr）与颈动脉内膜-中层厚度（IMT）的相关性，探讨SUA/SCr在2型糖尿病病人大血管并发症中的临床意义。方法收集127例2型糖尿病病人临床资料，根据病人颈动脉IMT厚度分为正常组（G1组）、内膜增厚组（G2组）、稳定斑块组（G3组）及不稳定斑块组（G4组）。统计并分析各组间临床资料的差异，对IMT和SUA/SCr进行相关性分析。结果各组间糖尿病病程差异有统计学意义（P < 0.01），各组间糖化血红蛋白（HbA1c）、血清低密度脂蛋白、胆固醇（LDL-C）水平、血清高密度脂蛋白胆固醇（HDL-C）水平及SUA/SCr差异有统计学意义（P < 0.01）；对颈动脉IMT增厚影响因素的logistic回归分析结果提示，病程、HbA1c、LDL-C、SUA/SCr可能是IMT增厚的风险因素（P < 0.05~P < 0.01），HDL-C是IMT增厚的保护性因素（P < 0.01）。结论在2型糖尿病病人中，糖尿病病程、HbA1c、LDL-C、SUA/SCr是IMT增厚的风险因素，HDL-C是IMT增厚的保护因素，在2型糖尿病伴有大血管并发症的病人中SUA/SCr的变化较SUA更为敏感。

Correlation analysis between the serum uric acid/creatinine value ratio and carotid intimal-media thickness in type 2 diabetes patients

ObjectiveTo explore the relationship between the serum uric acid to serum creatinine(SUA/SCr) ratio and carotid intima-media thickness(IMT) for analyzing the significance of the SUA/SCr ratio in the detection of large vascular complications in patients with type 2 diabetes.MethodsThe clinical data of 127 patients with type 2 diabetes were collected.According to the carotid IMT, the patients were divided into the normal group(group G1), intima thickened group(group G2), stable plaque group(group G3)and unstable plaque group(group G4).The differences of clinical data among four groups were statistically analyzed, and the relationship between IMT and SUA/SCr ratio was analyzed.ResultsThe differences of the course of diabetes among four groups were statistically significant(P < 0.01).The differences of the levels of glycosylated hemoglobin(HbA1c), serum LDL cholesterol(LDL-C), and serum HDL cholesterol(HDL-C) and SUA/SCr ratio among four groups were statistically significant(P < 0.01).The results of logistic regression analysis of influencing factors of carotid IMT showed that the disease course, and the levels of HbA1c, serum LDL-C and serum HDL-C and SUA/SCr ratio might be the risk factors of IMT(P < 0.05 to P < 0.01), and the HDL-C was a protective factor of IMT(P < 0.01).ConclusionsThe course of diabetes, HbA1c, LDL-C and SUA/SCr ratio are the risk factors of IMT, while the HDL-C is a protective factor of IMT in patients with type 2 diabetes.The change of SUA/SCr in patients with type 2 diabetes complicated with macrovascular complications is more sensitive than that of SUA.