HOXC8在人肝门部胆管癌中的表达及临床意义

目的 探讨HOXC8在人肝门部胆管癌组织中的表达及其对预后的影响。方法 采用免疫组化法检测49例肝门部胆管癌及对应癌旁正常组织中HOXC8蛋白的表达水平，并分析其与肝门部胆管癌患者临床病理特征及预后的关系。 结果 肝门部胆管癌组织中HOXC8蛋白的阳性表达率明显高于癌旁正常组织（57.1% vs 42.9%，P<0.001）。HOXC8表达与肝门部胆管癌患者肿瘤浸润深度、淋巴结转移、TNM分期有关（P<0.05）。单因素生存分析显示HOXC8阳性表达的肝门部胆管癌患者总生存期明显较HOXC8阴性表达患者差（12个月 vs 46个月，P<0.001），多因素回归分析显示HOXC8是肝门部胆管癌患者的独立预后因素（P=0.039）。 结论　HOXC8在肝门部胆管癌组织中高表达，且与不良预后有关，可能作为判断肝门部胆管癌患者预后的标志物及潜在治疗靶点。

Expression of HOXC8 in hilar cholangiocarcinoma and its clinical significance

 Objective To investigate the expression of HOXC8 in human hilar cholangiocarcinoma and its effect on prognosis.Methods The expression levels of HOXC8 protein in 49 cases of hilar cholangiocarcinoma and corresponding adjacent tissues were detected by tissue microarray and immunohistochemistry. The relationship of the expression of HOXC8 protein，the clinico-pathological features and prognosis of patients with hilar cholangiocarcinoma was analyzed. Results The positive expression rate of HOXC8 protein in hilar cholangiocarcinoma tissues was significantly higher than that in adjacent normal tissues（57.1% vs 42.9%，P<0.001）. HOXC8 expression was correlated with tumor invasion，lymph node metastasis，and TNM stage（P<0.05）. Univariate survival analysis showed that patients with positive expression of HOXC8 had poor overall survival than those with negative HOXC8 expression patients（12 months vs 46 months，P<0.001）. Multivariate regression analysis showed that HOXC8 was an independent prognostic factor for patients with hilar cholangiocarcinoma（P=0.039）. Conclusions HOXC8 is highly expressed in hilar cholangiocarcinoma and is associated with poor prognosis. HOXC8 may be used as a prognostic marker and potential therapeutic target for patients with hilar cholangiocarcinoma.