舌下含服粉尘螨滴剂对变应性鼻炎伴过敏性咳嗽病人的临床疗效及生活质量的影响

目的评估舌下特异性免疫治疗（SLIT）对变应性鼻炎（AR）伴过敏性咳嗽（AC）的临床疗效及生活质量的影响。方法选择96例6~55岁AR伴AC病人，随机分为SLIT组（52例）和对照组（44例）。对照组单纯抗过敏药物治疗，SLIT组在对照组基础上给予SLIT治疗。比较2组治疗前、治疗1年和2年时的鼻炎症状评分（TNSS）、日间咳嗽症状评分（DCSS）、夜间咳嗽症状评分（NCSS）、药物评分（TMS）、视觉模拟量表（VAS）评分和鼻-结膜炎生活质量问卷（RQLQ）评分情况。结果与治疗前比较，2组TNSS、DCSS、NCSS、TMS、VAS和RQLQ在治疗1年和2年时均降低（P < 0.01）；与治疗1年相比，SLIT组的VAS评分和RQLQ评分中的鼻部症状在治疗2年后进一步改善（P < 0.01和P < 0.05）。2组间TNSS、DCSS、NCSS、TMS、VAS和RQLQ治疗前差异无统计学意义（P>0.05），而治疗1年和2年后，SLIT组的TNSS、DCSS、NCSS、TMS、VAS和RQLQ均低于对照组（P < 0.05~P < 0.01）。结论对于AR伴AC的病人，SLIT联合药物治疗比单纯药物治疗具有更显著疗效，同时生活质量改善也更加明显。

Effect of the sublingual Dermatophagoides farinae drops treatment on the clinical effect and quality of life of patients with allergic rhinitis complicated with atopic cough

ObjectiveTo evaluate the effects of sublingual immunotherapy(SLIT) on clinical efficacy and quality of life of patients with allergic rhinitis(AR) complicated with atopic cough(AC).MethodsThe clinical data of 96 AR patients complicated with AC, aged 6-55 years, were retrospectively analyzed, and divided into the SLIT group(52 cases) and control group(44 cases).The control group was treated with simple anti-allergic drug, and the SLIT group were additionally treated with SLIT on the basis of control group.The TNSS, DCSS, NCSS, TMS, VAS and RQLQ scores were compared between two groups before treatment and after 1 year and 2 years of treatment.ResultsCompared with before treatment, the TNSS, DCSS, NCSS, TMS, VAS and RQLQ scores in two groups significantly decreased after 1 year and 2 years of treatment(P < 0.01), and the differences of those in two groups between before and after 1 year and 2 years of treatment were statistically significant(P < 0.01).Compared with after 1 year of treatment, the VAS and RQLQ scores in SLIT group were further improved after 2 years of treatment(P < 0.01 and P < 0.05).The differences of the TNSS, DCSS, NCSS, TMS, VAS and RQLQ scores between two groups before treatment were not statistically significant(P>0.05).After 1 year and 2 years of treatment, the TSS, DCSS, NCSS, TMS, VAS and RQLQ scores in SLIT group were lower than those in control group, and the difference of which were statistically significant(P < 0.05 to P < 0.01).ConclusionsFor AR patients complicated with AC, the treatment effects of SLIT combined with drugs is more significant than that of drug therapy alone, the improvement of quality of life is more significant.