锐性清创联合重组牛碱性成纤维细胞生长因子凝胶在慢性创面治疗中的应用

目的探讨锐性清创联合重组牛碱性成纤维细胞生长因子凝胶（bFGF）治疗慢性创面的效果。方法选择门诊治疗的慢性创面病人50例，随机分为对照组和观察组，各25例。对照组病人创面常规清创后，外用bFGF和银锌抑菌霜，每天换药1次。观察组病人创面进行首次锐性清创，之后常规换药，每次换药时用棉球擦拭创面至微微渗血，外用bFGF、银锌抑菌霜，每天换药1次。若创面2周内不能愈合，再行锐性清创术。比较2组病人创面第2、4、6周创面面积及愈合率。结果治疗第2周，2组病人创面面积差异有统计学意义（P < 0.01）；治疗第4、6周，2组病人创面面积均较第2周明显缩小（P < 0.01），且观察组病人创面面积均明显小于对照组（P < 0.01）。2组病人治疗第2周创面愈合率差异无统计学意义（P>0.05）；治疗第4、6周，观察组病人创面愈合率均明显高于对照组（P < 0.01）。结论锐性清创联合bFGF能有效促进慢性创面愈合。

Application of acute debridement combined with recombinant bovine basic fibroblast growth factor gel in the treatment of chronic wounds

ObjectiveTo investigate the effects of acute debridement combined with recombinant bovine basic fibroblast growth factor(bFGF) gel in treating chronic wounds.MethodsFifty patients with chronic wounds in outpatient were randomly divided into the control group and observation group(25 cases in each group).The control group was treated with external use of bFGF and silver zinc antibacterial cream after conventional debridement of wounds, change of dressing once a day.The observation group was treated with the first acute acute debridement on the wound surface, followed by a routine dressing change.During each dressing change, the wound surface was wiped with a cotton ball until the blood was slightly soaked, the bFGF and silver zinc antibacterial cream were externally applied, and the dressing was changed once a day.If the wound surface could not be healed within 2 weeks, the acute debridement was performed again.The wound area and healing rate were compared between two groups after 2, 4, and 6 weeks of treatment.ResultsThe difference of the wound area between two groups after 2 weeks of treatment was statistically significant(P < 0.01).After 4 and 6 weeks of treatment, the wound areas in two groups significantly shrinked compared with at 2 weeks of treatment(P < 0.01), and which in observation group was significantly less than that in control group(P < 0.01).The difference of the healing rate of wound between two groups after 2 weeks of treatment was not statistically significant(P>0.05).After 4 and 6 weeks of treatment, the healing rates of wound in observation group were significantly higher than those in control group(P < 0.01).ConclusionThe acute debridement combined with bFGF can significantly promote the healing of chronic wound.