The Therapeutic and Preventive Efficacy of Curcumin and Its Derivatives in Esophageal Cancer |
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Authors: | Komal Komal1Shilpi Chaudhary2Preeti Yadav3Raja Pramanik2Mayank Singh2 |
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Affiliation: | 1Department of Biochemistry All India Institute of Medical Sciences Delhi, New Delhi India.2Department of Medical Oncology BRAIRCH All India Institute of Medical Sciences Delhi, New Delhi, India.3Department of Microbiology Gargi College University of Delhi, New Delhi, India. |
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Abstract: | Esophageal cancer is the eighth most common occurring cancer type worldwide and 6th most common amongthe cancer related deaths of which the most common type is squamous cell carcinoma which comprise about 90%of esophageal cancer cases. The standard of care for esophageal cancer is neoadjuvant concurrent chemotherapy andradiation (NACRT) followed by surgery however the prognosis remains dismal with 5 year survival a meager 10-15%.The treatment modalities for esophageal cancer is associated with both long term and short term toxicities. Curcuminhas been explored as a therapeutic modality as a chemo adjuvant in different cancers due to its low toxicity profile andpotent anticancer effect however despite lot of promising preclinical data it has not progressed from bench side to bedside. The primary reason that has obstructed its application in clinic has been its low bioavailability which was seenin different clinical trials but there has been tremendous progress in developing formulations of curcumin which havesignificantly increased its bioavailability and are being tested in clinical trials. Esophageal cancer is associated withinflammation that’s why curcumin being a natural antioxidant offer a potential avenue to reduce toxicity of currenttherapeutic modalities in a chemo adjuvant setting while simultaneously targeting different pro oncogenic pathways.The present review tries to cover in depth different aspects of curcumin application in treatment of esophageal cancerand progress of this potent anticancer agent in its treatment and prevention. |
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Keywords: | curcumin Esophageal Cancer Chemoprevention |
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