| 神经元线粒体ATP敏感性钾通道与脑保护的研究进展 |
| |
| 引用本文： | 蔡扬帆,林霓阳. 神经元线粒体ATP敏感性钾通道与脑保护的研究进展[J]. 国外医学:内科学分册, 2007, 34(6): 362-365 |
| |
| 作者姓名： | 蔡扬帆 林霓阳 |
| |
| 作者单位： | 汕头大学医学院附属第一医院,广东汕头515041 |
| |
| 摘 要： | 线粒体ATP敏感性钾通道是一类存在于线粒体内膜并受胞内ATP浓度调节的钾离子通道.在脑的缺血再灌注损伤的病理生理过程中,ATP敏感性钾通道已经成为人们研究抗损伤的一个靶点.越来越多的研究表明线粒体ATP敏感性钾通道的激活可以保护神经元免受缺血缺氧及其它刺激所导致的细胞损伤及坏死.
|
| 关 键 词： | 线粒体ATP敏感性钾通道 脑 预处理 |
| 文章编号： | 1004-2369（2007）06-0362-04 |
| 修稿时间： | 2007-01-242007-03-20 |
The development of research on the relationship between neuroprotection and mitochondrial ATP-sensitive potassium channels in the brain |
| |
| CAI Yang-fan,LIN Ni-yang. The development of research on the relationship between neuroprotection and mitochondrial ATP-sensitive potassium channels in the brain[J]. Foreign Medical Sciences(Section of Internal Medicine), 2007, 34(6): 362-365 |
| |
| Authors: | CAI Yang-fan LIN Ni-yang |
| |
| Affiliation: | Department of Pediatrics, the First Affiliated Hospital, College of Medicine, Shantou University, Shantou 515041, China |
| |
| Abstract: | Mitochondrial ATP-sensitive potassium channels are located in the inner mitochondrial membrane (mio KATP), which are regulated by the ATP concentration in cytosole. In the physiopathologic process of ischemical reperfusion injury, mitoKATP channel has become a novel target of research on neuroprotection. More and more researches indicate that the activation of mitoKATP channels protect the neurons against injury and death caused by ischemic stress and other stimulus. |
| |
| Keywords: | Mitochondrial ATP-sensitive potassium channels Brain Preconditioning |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
