Complex synaptic responses of entorhinal cortical cells in the rat to subicular stimulation in vitro: demonstration of an NMDA receptor-mediated component |
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| Authors: | R S Jones |
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| Affiliation: | Department of Pharmacology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T. |
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| Abstract: | Intracellular recordings from neurones in the medial entorhinal cortex of the rat in vitro showed that the lowest threshold response to stimulation in the subiculum was a long latency, prolonged depolarization, which in extracellular records corresponded to a late, negative DC shift. These responses were reduced or abolished by 2-aminophosphonovalerate suggesting mediation via activation of amino acid receptors of the 'N-methyl-D-aspartate'-type. |
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