A cytotoxic xanthone dimer from the entomopathogenic fungus Aschersonia sp. BCC 8401 |
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| Authors: | Isaka Masahiko Palasarn Somporn Kocharin Kanokarn Saenboonrueng Janya |
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| Affiliation: | National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand. isaka@biotec.or.th |
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| Abstract: | Ascherxanthone A (1), a novel symmetrical tetrahydroxanthone dimer, was isolated from the entomopathogenic fungus Aschersonia sp. BCC 8401. The structure of 1 was elucidated by spectroscopic analysis, especially 2D-NMR. Compound 1 exhibited activity against Plasmodium falciparum K1 with an IC(50) value of 0.20 microg/mL, but it also showed cytotoxic activities against Vero cells and three tumor cell lines. |
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