| 用国产腺嘌呤制作大鼠慢性肾功能不全实验模型 |
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| 引用本文： | 石兴华,侯连兵,张中一,陈业豪,徐峰,丁彦青,潘振邦,王铁丹,肖应庆. 用国产腺嘌呤制作大鼠慢性肾功能不全实验模型[J]. 南方医科大学学报, 1991, 0(1) |
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| 作者姓名： | 石兴华 侯连兵 张中一 陈业豪 徐峰 丁彦青 潘振邦 王铁丹 肖应庆 |
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| 作者单位： | 南方医院药材科(石兴华，侯连兵，张中一，陈业豪，徐峰)，第一军医大学病理解剖学教研室(丁彦青)，南方医院肾内科(潘振邦)，第一军医大学生物化学教研室(王铁丹)，第一军医大学生物化学教研室(肖应庆) |
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| 摘 要： | 大鼠经0.75％腺嘌呤饲料长期喂养能引起与人体慢性肾功不全相类似的代谢异常。包括氮质血症,中分子物质蓄积及电解质代谢紊乱。病理可见:腺嘌呤组大鼠肾小管及肾间质严重损害。实验结果提示给大鼠30天腺嘌呤饲料能提供研究人体慢性肾功不全相类似的动物模型。
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| 关 键 词： | 腺嘌呤 慢性肾功不全 实验模型 |
Experimental model of adenine-induced chronic renal insufficiency in rats |
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| Shi Xinghua,et al. Experimental model of adenine-induced chronic renal insufficiency in rats[J]. Journal of Southern Medical University, 1991, 0(1) |
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| Authors: | Shi Xinghua et al |
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| Affiliation: | Shi Xinghua,et al Department of Pharmacy,Nanfang Hospital |
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| Abstract: | Long-term feeding of 0.75% adenine to rats produced metabolic abnormalities resembling chronic renal insufficiency in humans. These metabolic abnormalities included azotemia, aceumulation of middle molecule substances and metabolic perturbations of electrolytes, the pathological findings in the kidneys of these adenine rats revealed severe lesions of renal tubules and renal interstitial experimental results suggest that 30-day adenine feeding provides a model which would be useful for the study of chronic renal insufficiency. |
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| Keywords: | adenine chronic renal insufficiency animal model |
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