肾移植术后应用五酯胶囊增加他克莫司血药浓度的疗效分析

目的]研究旨在观察五酯胶囊对肾移植术后他克莫司血药浓度的影响.方法]选取60例肾移植术后患者,随机分为试验组和对照组.试验组给予患者早上和晚上口服他克莫司胶囊同时加服五酯胶囊,对照组则仅口服他克莫司胶囊,调整他克莫司血药浓度在正常范围内.4周后,他克莫司剂量和肝肾功能的变化在两组进行比较.结果]两组患者在年龄、体...

Analysis of the effect of increasing the blood concentration of Tacrolimus with Wuzhi Capsule after kidney transplantation

Objective] The purpose of this study was to observe the effect of Wuzhi Capsule on the blood concentration of tacrolimus after renal transplantation. Methods] The 60 patients after kidney transplantation were randomly divided into experimental group and control group. Patients in the experimental group were given Tacrolimus Capsule orally in the morning and evening and Wuzhi Capsule in addition,while patients in the control group were given Wuzhi Capsule only orally,and the blood concentration of Tacrolimus was adjusted within the normal range. After 4 weeks,Tacrolimus dose and changes in liver and kidney function were compared between the two groups. Results] There were no statistically significant differences in age,weight or postoperative duration between the two groups (P>0.05),between two groups after 4 weeks of Tacrolimus blood concentrations and liver and kidney function not statistical difference (P>0.05),while the experimental group than control group in using of Tacrolimus Capsule dosage significantly reduced,statistically significant (P=0.008 3). Conclusion] After kidney transplantation,Wuzhi Capsule were added to ensure that tacrolimus could reach an appropriate blood concentration,so as to reduce the economic burden of patients and produce greater social benefits.