| 羟甲基戊二酰辅酶A还原酶抑制剂的研究进展 |
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| 引用本文： | 张哲峰,刘铁钢,张冬. 羟甲基戊二酰辅酶A还原酶抑制剂的研究进展[J]. 中国现代应用药学, 1999, 16(6): 1-4 |
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| 作者姓名： | 张哲峰 刘铁钢 张冬 |
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| 作者单位： | 石家庄,050011,河北省药品检验所 |
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| 摘 要： | 目的：介绍ＨＭＧＣｏＡ 还原酶抑制剂类药的研究进展，为临床合理用药提供参考。方法：以国内外发表的论文为基础，经分析，归纳，从药理作用、体内过程、临床应用、副作用及产品发展概况等方面介绍洛伐他汀、普伐他汀、辛伐他汀、氟伐他汀及西伐他汀等药品。结果与结论：大量资料表明，ＨＭＧＣｏＡ 还原酶抑制剂是一类疗效显著、毒副作用少，耐受性好的理想降血脂药物，该类药的问世为治疗高胆固醇血症开辟了新途径。
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| 关 键 词： | HMG-CoA还原酶抑制剂 洛伐他汀 普伐他汀 辛伐他汀 氟伐他汀 西伐他汀 |
| 修稿时间： | 1998-07-27 |
The advancement of HMG CoA reductase inhibitor |
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| Zhang Zhefeng(Zhang ZF,Liu Tiegang(Liu TG,Zhang Dong(Zhang D. The advancement of HMG CoA reductase inhibitor[J]. The Chinese Journal of Modern Applied Pharmacy, 1999, 16(6): 1-4 |
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| Authors: | Zhang Zhefeng(Zhang ZF Liu Tiegang(Liu TG Zhang Dong(Zhang D |
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| Affiliation: | Zhang Zhefeng(Zhang ZF),LiuTiegang(Liu TG),Zhang Dong(Zhang D)(Hebei Provincial Institute for DrugControl,Shijiazhuang 050011) |
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| Abstract: | OBJECTIVE:To introduce the advancement of HMG CoA reductase inhibitors and provide references for the safe and effective application of these medicines in clinical treatment.METHOD:According to articles published,mechanisums,pharmacokinetics,pharmacodynamics,clinical uses and products development of lovastatin,provastatin,simvastatin,fluvastatin,and cerivastatin were reviewed.RESULTS and CONCLUSION:From these information it is suggested that HMG CoA RI is a kind of safe,effective and tolerable lipid modulators. |
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| Keywords: | HMG CoA RI lovastatin provastatin simvastatin fluvastatin cerivastatin |
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