| 葛根素对大鼠急性脑缺血损伤Hsp70表达的影响 |
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| 引用本文： | 潘洪平,莫祥兰,杨嘉珍,李吕力,黄振录,叶劲,黄进. 葛根素对大鼠急性脑缺血损伤Hsp70表达的影响[J]. 中国中药杂志, 2005, 30(7): 538-540 |
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| 作者姓名： | 潘洪平 莫祥兰 杨嘉珍 李吕力 黄振录 叶劲 黄进 |
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| 作者单位： | 广西壮族自治区人民医院,广西,南宁,530021 |
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| 基金项目： | 广西卫生厅医药卫生科研项目 |
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| 摘 要： | 目的:探讨葛根素对大鼠急性脑缺血损伤Hsp70表达的影响。方法:采用闭夹大脑中动脉造成局部脑缺血模型,对脑组织用免疫组化SP法作Hsp70染色,观察其Hsp70表达情况。结果:葛根素干预组Hsp70表达强度显著强于单纯缺血组(P<001)。结论:葛根素有上调大鼠急性脑缺血损伤时Hsp70表达的作用。
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| 关 键 词： | 葛根素注射液 急性脑缺血 Hsp70 |
| 文章编号： | 1001-5302(2005)07-0538-03 |
| 收稿时间： | 2004-08-26 |
Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia |
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| PAN Hong-ping;MO Xiang-lan;YANG Jia-zhen;LI Lu-li;HUANG Zhen-lu;YE Jin;HUANG Jin. Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia[J]. China Journal of Chinese Materia Medica, 2005, 30(7): 538-540 |
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| Authors: | PAN Hong-ping MO Xiang-lan YANG Jia-zhen LI Lu-li HUANG Zhen-lu YE Jin HUANG Jin |
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| Abstract: | Objective: To study the effect of puerarin on the expression of Hsp(heat shock protein)70 in the rats with cerebral injury induced by acute local ischemia. Method: Rat model of acute local cerebral ischemia was made by ligating middle cerebral artery. The Hsp70 expression in brain tissue was detected by SP method of immunohistochemistry. Result: The expression of Hsp70 was significantly higher in puerarintreated rats than those in the rats with cerebral ischemia. Conclusion: Puerarin can enhance the level of Hsp70 expression in the rats with cerebral injury induced by acute local ischemia. |
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| Keywords: | Puerarin acute cerebral ischemia Hsp70 rat |
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