蝉蜕水煎剂对未孕大鼠离体子宫平滑肌作用的研究

目的:观察蝉蜕水煎剂对未孕大鼠离体子宫平滑肌运动的影响,并初步探讨其作用机制。方法:运用BL-420生物信号系统记录未孕大鼠离体子宫平滑肌条的活动,观察不同剂量蝉蜕水煎剂对子宫平滑肌自发活动的影响。结果:蝉蜕水煎剂对未孕大鼠离体子宫平滑肌有明显地兴奋作用,可增加其收缩波持续时间,增加收缩张力及子宫活动力,并呈量效关系。蝉蜕水煎剂的这一作用可被异搏定(L型电压依从性Ca2 通道阻断剂)完全阻断(P<0.01)。结论:蝉蜕水煎剂在体外可增强子宫平滑肌的收缩,该作用可能是通过L型钙通道而发挥作用的。

Research on the Effect of Periostracan Cicadae Decoction on Isolated uterus Smooth Muscle in Non-pregnant Rats

Objective:To observe the effect of periostracan cicadae decoction on isolated uterus smooth muscle in pregnant rats,and investigate preliminarily the mechanism.Methods:To observe the effect of different dosage periostracan cicadae decoction on the spontaneous activity of uterus smooth muscle in pregnant rats by BL-420 biological signaling system writting down the activity of isolated uterus smooth muscle.Results:Periostracan cicadae decoction obviously excited the contractive force and the activity of uterus,and can dose dependently extend the endurance time of contraction waves.The effect is completely blocked by verapamil(L-type voltage dependent Ca2 channels blocker)(P<0.01).Conclusion:Periostracan cicadae decoction can enhance constriction of isolated uterus smooth muscle possibly by L-type Ca2 channels.