淋巴瘤患者外周血白细胞和淋巴细胞GCR表达及与化疗效果关系的研究

目的 :探讨糖皮质激素受体 (GCR)在淋巴瘤中的表达规律及与化疗敏感性的关系。方法 :采用3H- DEX测定淋巴瘤患者外周血淋巴细胞和白细胞膜 GCR位点表达 ,同时观察淋巴细胞和白细胞 GCR位点数与化疗敏感性的关系。结果 :淋巴瘤患者外周血白细胞和淋巴细胞 GCR表达总体无差异 ,但淋巴细胞 GCR高表达者较白细胞高者对化疗反应性好 ,化疗不影响 GCR表达。结论 :淋巴瘤患者外周血淋巴细胞的测定对预测糖皮质激素 (GC)疗效较外周血白细胞更有价值

Observation of GCR expression of peripheral blood leucocyte and study of lymphocyte and study of curative effect in lymphoma

Objective:To study the relation between GCR expression and sensitivity of chemotherapy in patients with lymphoma.Methods:GCR sites in membrane of peripheral blood leucocyte and lymphocyte were determined by 3H-DEX,and the relation between the number of GCR site and sensitivity of chemotherapy was observed.Results:GCR expression of leucocyte and lymphocyte was basically at the same level,but patients with high GCR expression of lymphocyte were more sensitive to chemotherapy than those with high GCR expression of leucocyte, and chemotherapy did not affect the GCR expression.Conclusion:Determination of peripherial blood lymphocyte GCR is of greater value to prediction of curative effect of GC than that of leucocyte.