血清同型半胱氨酸的研究进展

同型半胱氨酸(Hcy)是含巯基氨基酸,从细胞内的甲硫氨酸代谢中起源,为甲硫氨酸代谢的中间产物。血中总Hcy水平受许多因素的影响,如参与Hcy代谢酶的基因遗传变异、某些药物、肾衰竭、性别与年龄、雌激素缺乏、Hcy代谢所需辅助因子缺乏如叶酸、维生素B2、维生素B6、维生素B12等。近期的研究表明:高同型半胱氨酸血症是冠状动脉疾病、脑血管疾病、外周血管疾病独立的危险因子,也是有效的预测因子,并具有较高的临床应用价值。

Research Progress on Serum Homocysteine

Homocysteine (Hcy) is a sulphate-containing amino acid,which originated from methionine metabolism and its intermediate product.The total Hcy level in serum is affected by many factors,which includes gene autogenous variation of Hcy metabolic enzyme,some drugs,renal failure,sex and age,absence of estrogen,lack of co-factor needed in Hcy metabolism such as folic acid,vitamin B2,vitamin B6,vitamin B12 and so on.Recent studies showed that high Hcy level is the independent risk factor and effective predictor of coronary artery disease,cerebrovascular disease and peripheral angiopathy,which also has high value in clinical application.