| PD-L1在结肠癌患者CD4＋CD25hiCD127low／-调节性 T 细胞中的表达及其临床意义 |
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| 引用本文： | 梁姣姣,居颂文,高志欣.PD-L1在结肠癌患者CD4＋CD25hiCD127low／-调节性 T 细胞中的表达及其临床意义[J].重庆医学,2015(31):4324-4326. |
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| 作者姓名： | 梁姣姣 居颂文 高志欣 |
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| 作者单位： | 1. 南京医科大学附属苏州医院北区消化系疾病与营养研究中心,苏州,215008;2. 南京医科大学附属苏州医院北区消化科,苏州,215008 |
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| 基金项目： | 国家自然科学基金资助项目，江苏省科技计划项目，苏州市科技计划项目资助 |
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| 摘 要： | 目的：探讨PD‐L1在结肠癌患者外周血CD4＋ CD25hi CD127low／‐T reg细胞上的表达及其与肿瘤病理分期之间的相关性。方法采用流式细胞术分析了47例结肠癌患者外周血中CD4＋CD25hi CD127low／‐T reg细胞的含量及其PD‐L1的表达。结果和健康人比较，结肠癌患者外周血中CD4＋CD25hi CD127low／‐T reg细胞的含量显著上升，并且PD‐L1的表达明显升高。进一步的分析表明，PD‐L1的表达和结肠癌的病理分期呈正相关，而术后患者CD4＋ CD25hi CD127low／‐T reg细胞 PD‐L1的表达则显著下降。结论 CD4＋CD25hi CD127low／‐T reg细胞数量及PD‐L1表达的升高可能导致了免疫抑制的增强，这可能是促进肿瘤免疫逃逸的重要因素。
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| 关 键 词： | PD-L1 结肠癌 CD4%2BCD25hi CD127low/-T reg细胞 |
The clinical expression significance of PD-L1 on the CD4+CD25hi CD127low/- Treg cells in the peripheral blood of colon cancer |
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| Abstract: | Objective To investigate the expression of PD‐L1 in the CD4+CD25hiCD127low/‐ Treg cells in the peripheral blood of colon cancer and the correlation with clinical stage .Methods The expression of PD‐L1 on CD4+CD25hiCD127low/‐Treg cells from 47 samples of the peripheral blood of colon cancer was analyzed by flow cytometry .Results Compared with those from healthy do‐nor ,the proportion of CD4+CD25hiCD127low/‐Treg cells and expression of PD‐L1 on these cells increased significantly (P<0 .01) . Further analysis showed that expression of PD‐L1 increased with the increase of clinical stage of colon cancer (P<0 .01) ,and de‐creased significantly after postoperation (P<0 .05) .Conclusion Increase of proportion of CD4+CD25hiCD127low/‐Treg cells and the expression of PD‐L1 may enhance the suppression of antitumor immunity ,and thereby promote tumor immunoescape . |
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| Keywords: | PD-L1 colonic neoplasms T-lymphocytes regulatory CD4+CD25hiCD127low/- |
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