Short Report: Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen |
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Authors: | Craddock C Bardy P Kreiter S Johnston R Apperley J Marks D Huber C Kolbe K Goulding R Lawler M Goldman J Hughes T Derigs G |
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Institution: | Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK. Charles.Craddock@university-b.wmids.nhs.uk |
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Abstract: | Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens. |
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Keywords: | GVHD stem cell transplantation T-cell depletion reduced intensity conditioning |
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