| 灵丹散对四氯化碳致肝损伤大鼠肝功能及肝纤维化的影响 |
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| 引用本文： | 何颖颖,李锋,马亮,孙香蕾,石德祥. 灵丹散对四氯化碳致肝损伤大鼠肝功能及肝纤维化的影响[J]. 中国中医急症, 2011, 20(6): 920-921 |
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| 作者姓名： | 何颖颖 李锋 马亮 孙香蕾 石德祥 |
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| 作者单位： | 1. 第四军医大学西京医院,陕西西安,710023
2. 陕西省结核病防治院,陕西西安,710023 |
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| 摘 要： | 目的观察中药复方灵丹散对实验性四氯化碳致肝损伤大鼠的疗效。方法健康SD大鼠分为正常对照组、模型组、复方鳖甲软肝片对照组、灵丹散组。采用皮下注射四氯化碳制备细胞毒性肝硬化大鼠模型,各用药组自造模4周起开始灌胃中药,共用药5周。HE染色观察肝组织纤维化病理改变。试剂盒法检测血清AST、ALT、Alb等的活性,放射免疫法法检测肝纤维化指标-透明质酸（HA）、层黏蛋白（LN）、Ⅳ型胶原（C-Ⅳ）、Ⅲ型前胶原（PCⅢ）。结果与正常组大鼠比较,模型组大鼠血清肝功能异常,肝纤维化四项指标明显升高,肝组织纤维化改变明显,灵丹散显著改善模型组大鼠肝功能及肝组织的纤维化病理改变。结论灵丹散可有效改善四氯化碳致肝损伤大鼠的肝功能及肝组织纤维化。
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| 关 键 词： | 灵丹散 肝损伤 四氯化碳 肝功能 纤肝维化 |
Effects of Lingdan Powder on Liver Function and Liver Fibre of Rats Induced by CCl4 |
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| HE Ying-ying,LI Feng,MA Liang,et al Xijing Hospital of Fourth Military Medical University. Effects of Lingdan Powder on Liver Function and Liver Fibre of Rats Induced by CCl4[J]. Journal of Emergency in Traditional Chinese Medicine, 2011, 20(6): 920-921 |
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| Authors: | HE Ying-ying LI Feng MA Liang et al Xijing Hospital of Fourth Military Medical University |
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| Affiliation: | HE Ying-ying,LI Feng,MA Liang,et al Xijing Hospital of Fourth Military Medical University(Xi'an 710023,Shaanxi) |
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| Abstract: | Objective:To observe the effects of compound Lingdan Powder on liver function and liver fibre of rats induced by CCl4.Methods:40 rats were divided into the normal control group,the model group,the Compound Biejiaruangan Tablet group and the Lingdan Powder group.Rats models induced by CCl4 were fed the Chinese herb after 4 weeks of model establishment.After 5 weeks feeding,these indices were observed including the liver tissue fibre pathology change,the AST,the ALT,the ALB and fibre indices.Results:Compared ... |
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| Keywords: | Lingdan Powder Liver damage CCl4 Liver function Liver fibre |
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