|
|||||
|
|
Nephrotoxicity of intravenous colistin: a prospective evaluation |
|
| Authors: | Falagas Matthew E Fragoulis Konstantinos N Kasiakou Sofia K Sermaidis George J Michalopoulos Argyris |
| Institution: | aAlfa Institute of Biomedical Sciences (AIBS), Athens, Greece bDepartment of Medicine, Tufts University School of Medicine, Boston, MA, USA cDepartment of Medicine, ‘Henry Dunant’ Hospital, Athens, Greece dIntensive Care Unit, ‘Henry Dunant’ Hospital, Athens, Greece |
| Abstract: | Twenty-one patients who received intravenous colistimethate sodium (CMS) for at least 7 days for the treatment of multidrug-resistant Gram-negative bacterial infections were included in a prospective cohort study at ‘Henry Dunant’ Hospital in Athens, Greece. The mean (± standard deviation) and median daily doses, cumulative doses and duration of treatment of intravenous CMS were, respectively, 5.5 (± 1.9) and 6 million IU, 90.2 (± 52.0) and 72 million IU, and 17.7 (± 11.7) and 15 days (range 7–54 days). Three patients (14.3%) developed nephrotoxicity during treatment with CMS. The cumulative dose of administered CMS was statistically correlated with the difference in values of serum creatinine between the end and start of CMS treatment (r = 0.6, P = 0.004 by Spearman's test). |
| Keywords: | Colistin Polymyxin E Multidrug-resistant Gram-negative bacteria Infections Renal dysfunction Acute renal failure Acute tubular necrosis Serum creatinine Urine creatinine |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |