| 化疗诱发非小细胞肺癌患者Ⅳ度粒细胞减少的相关因素分析 |
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| 引用本文： | 王根和,吴怡青,方平,汪曙红.化疗诱发非小细胞肺癌患者Ⅳ度粒细胞减少的相关因素分析[J].中国肿瘤临床与康复,2010(1):30-32. |
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| 作者姓名： | 王根和 吴怡青 方平 汪曙红 |
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| 作者单位： | 安徽省黄山市人民医院肿瘤科; |
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| 摘 要： | 目的分析非小细胞肺癌患者化疗诱发的Ⅳ度粒细胞减少的相关因素,为合理使用人粒细胞集落刺激因子提供依据。方法收集化疗诱发的Ⅳ度粒细胞减少的非小细胞肺癌患者的临床资料（A组）,以同期化疗未出现粒细胞减少的非小细胞肺癌患者作为对照组（B组）,采用单因素和多因素分析其危险因素。结果单因素分析显示,非小细胞肺癌患者出现Ⅳ度粒细胞减少的相关因素为PS2分、临床分期Ⅳ期、化疗前1周内使用GCSF、化疗延期大于1周、化疗周期数≥4个、多西紫杉醇＋顺铂方案、合并放射治疗。多因素分析显示,出现Ⅳ度粒细胞减少的相关因素为临床分期Ⅳ期、化疗前1周内使用GCSF、化疗延期大于1周、化疗周期数≥4个、多西紫杉醇＋顺铂方案。结论Ⅳ度粒细胞减少的危险因素为临床分期Ⅳ期、化疗前1周内使用GCSF、化疗延期大于1周、化疗周期数≥4个、多西紫杉醇＋顺铂方案。高风险患者应该预防性应用GCSF。
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| 关 键 词： | 肺肿瘤 Ⅳ粒细胞减少 人粒细胞集落刺激因子 |
Clinical analysis of risk factors for grade-4 neutropenia induced by chemotherapy in the non-small cell lung cancer |
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| WANG Gen-he,WU Yi-qing,FANG Ping,et al.Clinical analysis of risk factors for grade-4 neutropenia induced by chemotherapy in the non-small cell lung cancer[J].Chinese Journal of Clinical Oncology and Rehabilitation,2010(1):30-32. |
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| Authors: | WANG Gen-he WU Yi-qing FANG Ping |
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| Institution: | WANG Gen-he,WU Yi-qing,FANG Ping,et al(Department of Oncology,the People\'s Hospital of Huangshan,Anhui Province,Huangshan City,245000,China) |
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| Abstract: | Objective To analyze the risk factors for grade-4 neutropenia induced by chemotherapy in the non-small cell lung cancer and to provide evidence for the proper use of recombinant human granulocyte colony-stimulating Factor(rhG-CSF).Methods Patients with non-small cell lung cancer and grade-4 neutropenia induced by chemotherapy were selected(group A),and patients without chemotherapy-induced neutropenia were selected as control(group B).The risk factors were analyzed.Results In univariate analysis,the risk fa... |
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| Keywords: | Lung neoplasms Neutropenia Recombinant human granulocyte colony stimulating factor |
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