| BDNF及其受体TrkB在不同程度癫痫患者颞叶或海马中的差异性表达 |
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| 引用本文： | 赵姝,韩大勇,王秀杰.BDNF及其受体TrkB在不同程度癫痫患者颞叶或海马中的差异性表达[J].黑龙江医学,2011,35(9):641-644,649. |
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| 作者姓名： | 赵姝 韩大勇 王秀杰 |
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| 作者单位： | 哈尔滨医科大学附属第一医院急诊内科,黑龙江,哈尔滨,150001 |
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| 摘 要： | 目的 检测不同发病程度的癫痫患者颞叶或海马中脑源性神经营养因子(BDNF)及其酪氨酸激酶B 受体(TrkB)差异性表达情况,探讨其在癫痫发病机制中的作用.方法 取82例癫痫患者颞叶或海马脑组织,用免疫组化方法检测BDNF及其受体TrkB的表达,分析不同病程和发作频率患者脑组织中BDNF及TrkB的表达差异.结果 癫痫患...
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| 关 键 词： | 脑源性神经营养因子 酪氨酸激酶B受体 癫痫 |
The Expression of BDNF and Receptor TrkBin the Brains of Intractable Epilepsy |
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| ZHAO Shu,HAN Da-yong,WANG Xiu-jie.The Expression of BDNF and Receptor TrkBin the Brains of Intractable Epilepsy[J].Heilongjiang Medical Journal,2011,35(9):641-644,649. |
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| Authors: | ZHAO Shu HAN Da-yong WANG Xiu-jie |
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| Institution: | ZHAO Shu,HAN Da-yong,WANG Xiu-jie(Department of Emergency Internal Medicine,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,CHINA) |
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| Abstract: | Objective To investigate the expression of brain derived neurotrophic factor(BDNF) and its receptor TrkB in the brain tissues of epilepsy.To discuss its function in the epilepsy pathogenesis.Methods 82 cases of hippocampus and temporal lobe brain tissues were studied.The expression of BDNF and TrkB were investigated by Immunohistochemistry.The patients with different pathogenesis and seizure frequency were analyzed.Results The expression of BDNF/TrkB protein was significantly increased in temporal lobe cort... |
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| Keywords: | Brain derived neurotrophic factor Trkb Epilepsy |
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