Role of Gamma Interferon in Controlling Murine Chlamydial Genital Tract Infection |
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| Authors: | James I. Ito and Joseph M. Lyons |
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| Affiliation: | Department of Infectious Diseases, City of Hope National Medical Center, Duarte, California 91010, USA. jito@coh.org |
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| Abstract: | Earlier investigations have not shown an important role for gamma interferon (IFN-gamma) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-gamma and IFN-gamma receptor knockout mice, we were able to demonstrate a major role for IFN-gamma in mediating control of infection throughout the course of infection. |
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