Ampicillin‐ and ampicillin/sulbactam‐resistant Escherichia coli infection in a neonatal intensive care unit in Japan |
| |
| Authors: | Ken Saida Yukako Ito Yosuke Shima Eriko Kasuga Mai Kusakari Yukihide Miyosawa Atsushi Baba |
| |
| Institution: | 1. Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan;2. Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan |
| |
| Abstract: | The incidence of ampicillin (ABPC)‐resistant Escherichia coli (E. coli) infection in very low‐birthweight infants has been increasing. The rate of ABPC/sulbactam (ABPC/SBT)‐resistant E. coli in this population, however, is currently unknown. We encountered two cases of severe infection due to resistant E. coli and retrospectively studied the prevalence of ABPC‐ and ABPC/SBT‐resistant E. coli in regular surveillance cultures obtained from all neonatal intensive care unit (NICU) patients between 2000 and 2013. The overall prevalence of ABPC‐resistant E. coli was 39% (47/120), accounting for 63% of cases (32/51) between 2007 and 2013, compared with 22% (15/69) between 2000 and 2006. The prevalence of ABPC/SBT resistance was 17% (20/120), which was similar in both periods (16%, 8/51 vs 17%, 12/69). According to these results, not only ABPC, but also ABPC/SBT‐resistant E. coli must be considered in the NICU. |
| |
| Keywords: | ampicillin ampicillin/sulbactam Escherichia coli neonatal intensive care unit prevalence |
|
|
