Total neoadjuvant therapy for rectal cancer |
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Authors: | K.A. Goodman |
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Affiliation: | University of Colorado Cancer Center, Professor, Department of Radiation Oncology, University of Colorado School of Medicine, 1665 Aurora Court, Suite 1032 MS F706, Aurora, CO 80045, USA |
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Abstract: | While outcomes for patients with locally advanced disease have improved considerably with combined modality therapy, there is now an emphasis on developing risk-adapted treatment strategies. Moreover, the primary cause of death from locally advanced rectal cancer is related to distant progression, which now exceeds the rate of local failure. Thus, the necessity to optimally address micrometastatic disease has led to increasing interest in delivering chemotherapy in the neoadjuvant setting rather than in the postoperative setting. This review critically appraises the emerging literature on the options for sequencing of therapy, focusing on the total neoadjuvant therapy paradigm as well as emerging options for omitting components of multimodality therapy. |
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Keywords: | Induction chemotherapy Locally advanced rectal cancer Total neoadjuvant therapy Chemoradiation Chimiothérapie d’induction Cancer rectal localement évolué Thérapie néoadjuvante totale Chimioradiothérapie |
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