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小青龙汤和麻黄汤抗组胺作用
引用本文:阮岩,李笋,封彦蕾,陈蔚. 小青龙汤和麻黄汤抗组胺作用[J]. 中药新药与临床药理, 2006, 17(2): 144-147
作者姓名:阮岩  李笋  封彦蕾  陈蔚
作者单位:1. 广州中医药大学第一附属医院耳鼻咽喉科,广州,510405
2. 广州中医药大学附属祁福医院,广州,510200
摘    要:目的利用组胺皮肤试验了解中药抗组胺机理,比较中西药抗组胺作用的异同。方法将45例健康志愿者分为小青龙汤组,麻黄汤组,氯雷他定组和安慰剂组,各组在用药前及用药后2,5,24h进行不同浓度的组胺皮肤试验,皮试后15min观察并记录风团及红晕的面积,绘制剂量-反应曲线。结果风团和红晕面积比较,小青龙汤、麻黄汤组服药后2,5,24h和服药前差异无显著性(P>0.05)。氯雷他定组服药后2,5,24h和服药前差异有显著性(P<0.05)。结论小青龙汤和麻黄汤不能直接抑制组胺,而可能是抑制肥大细胞脱颗粒作用,减少组胺的分泌。

关 键 词:小清龙汤  麻黄汤  抗组胺作用  皮肤试验
文章编号:1003-9783(2005)05-0144-04
收稿时间:2005-09-30
修稿时间:2005-09-30

Antihistamine Action of Small - blue - dragon Decoction and Mahuang Decoction
RUAN Yan,LI Sun,FENG Yanlei,CHEN Wei. Antihistamine Action of Small - blue - dragon Decoction and Mahuang Decoction[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2006, 17(2): 144-147
Authors:RUAN Yan  LI Sun  FENG Yanlei  CHEN Wei
Affiliation:1. The First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405; 2. Qifu Hospital, the Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510200
Abstract:Objective To investigate the antihistamine mechanism of Chinese herbal medicine by histamine-skin experiments and to campare the effective similarities and differences between the Chinese herbal medicine and the western medicine. Method The 45 healthy volunteers were divided into 4 groups:Small-blue-dragon Decoction group,Mahuang Decoction group,loratadine group and placebo group. In each group,histamine skin tests (histamine concentrations with 20.0 , 7.3 , 2.7 , 1.0 mmol/L ) were performed before treatment and after treatment for 2,5,24 hours. 15 minutes later,after skin tests,wheal and flare areas were measured,the AUDRC ( area under dose-response curve, AUDRC) were drawed. Result Compared with pre-administration,the wheal and flare areas have no significant difference in Small-blue-dragon Decoction group and Mahuang Decoction group (P > 0.05),while loratadine group shows a highly significant treatment efficacy(P < 0.05). Conclusion Probably the Chinese herbal medicine is to repress the mastocyte taking off the grain function and to reduce histamine secretion sequentially.
Keywords:Small-blue-dragon Decoction  Mahuang Decoction  Antihistamine  Skin-tests
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