血清基质金属蛋白酶-1,2,9在高血压并发急性冠脉综合征中的变化

目的：探讨血清基质金属蛋白酶-1，2，9（matrix metalloproteinases 1，2，9，MMP-1，2，9）在高血压并发急性冠脉综合征（acute coronary syndrome，ACS）中的变化及其临床意义。方法：正常组22例，高血压组（HBP组）26例，ACS组49例，HBP＋ACS组47例。用酶联免疫吸附法（enzyme linked immunosorbent assay，EHSA）检测各组血清MMP-1，2，9水平，免疫散射比浊法（immunoturbidimetric method）检测血清C反应蛋白（C-reactive protein，CRP）水平。分析HBP＋ACS组阳性值的血清MMP-1，2，9水平，受试者工作特性曲线（receiver operating characteristic curve，ROC）。结果：HBP＋ACS组血清MMP-1，2，9水平显著高于正常组、HBP组及ACS组（P〈0．01），MMP-1，2，9水平与血清CRP水平呈正相关。MMP—1，2，9水平用于HBP＋ACS判断的临界值分别为33．25ng／ml、613．18ng／ml和241．14ng／ml，ROC曲线下面积分别为0．763、0．858和0．895，MMP-9阳性似然比、阳性预测值及阴性预测值高于MMP-1和MMP-2，阴性似然比低于MMP-1和MMP-2。结论：血清MMP—1，2，9在HBP＋ACS中呈高表达，提示血清MMP—1，2，9变化与高血压并发ACS发生发展有关,MMP-9作为预测动脉粥样斑块不稳定或破裂的血清学指标优于MMP-1和MMP-2。

Changes of MMP-1,2,9 in hypertension complicated by acute coronary syndrome

Objective:To explore the changes of MMP-1,2,9 in hypertension (HBP) complicated by acute coronary syndrome (ACS) and to evaluate their clinical significance.Methods:47 patients with hypertension complicated by ACS were enrolled as HBP+ACS group,and 49 patients with simple ACS as ACS group and 26 patients with simple hypertension as HBP group,22 health volunteers served as control group.MMP -1,2,9 in serum were measured with ELISA,CRP in serum was measured with immunoturbidimetric method. The receiver operat...