| 18F-FDG PET/CT监测免疫相关不良反应的临床应用 |
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| 引用本文： | 王静楠,王雪竹,杨旭,赵海涛,张力,王颖轶,李方,霍力. 18F-FDG PET/CT监测免疫相关不良反应的临床应用[J]. 中华核医学与分子影像杂志, 2022, 0(2) |
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| 作者姓名： | 王静楠 王雪竹 杨旭 赵海涛 张力 王颖轶 李方 霍力 |
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| 作者单位： | 中国医学科学院、北京协和医学院北京协和医院核医学科、核医学分子靶向诊疗北京市重点实验室;中国医学科学院、北京协和医学院北京协和医院肝脏外科;中国医学科学院、北京协和医学院北京协和医院呼吸内科;中国医学科学院、北京协和医学院北京协和医院肿瘤内科 |
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| 基金项目： | 中国医学科学院医学与健康科技创新工程 (2018-I2M-3-001)。 |
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| 摘 要： | 免疫检查点抑制剂(ICIs)在国内外临床试验的多种恶性肿瘤治疗中表现出了显著的疗效,在我国已被批准进入临床应用。ICIs治疗引起的免疫相关不良反应(irAEs)可发生于任何器官,早期发现和临床干预能够改善患者预后。18F-FDG PET/CT有助于早期发现irAEs,为临床诊疗提供正确的指导。该文旨在对18F-FDG PET/CT在监测irAEs的临床应用进行综述,总结其典型影像学表现和研究进展。
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| 关 键 词： | 免疫相关不良反应 免疫检查点抑制剂 正电子发射断层显像术 体层摄影术,X线计算机 氟脱氧葡萄糖F18 发展趋势 |
18F-FDG PET/CT in detecting immune-related adverse events |
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| Wang Jingnan,Wang Xuezhu,Yang Xu,Zhao Haitao,Zhang Li,Wang Yingyi,Li Fang,Huo Li. 18F-FDG PET/CT in detecting immune-related adverse events[J]. Chinese Journal of Nuclear Medicine, 2022, 0(2) |
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| Authors: | Wang Jingnan Wang Xuezhu Yang Xu Zhao Haitao Zhang Li Wang Yingyi Li Fang Huo Li |
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| Affiliation: | (Department of Nuclear Medicine,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine,Beijing 100730;Department of Liver Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730;Department of Respiratory,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730;Department of Oncology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730) |
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| Abstract: | Immune checkpoint inhibitors(ICIs)have shown significant efficacy in clinical trials and applications of various malignant tumors,and have been approved for clinical application in China.ICIs can cause immune-related adverse events(irAEs),which may affect any organs.Early identification and appropriate treatment can improve patient outcome.18F-FDG PET/CT is capable of early detection of irAEs and provides effective clinical guidance.This article reviews the clinical application of18F-FDG PET/CT in detecting irAEs,including typical imaging findings and research progress. |
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| Keywords: | Immune-related adverse events Immune checkpoint inhibitors Positron-emission tomography Tomography,X-ray computed Fluorodeoxyglucose F18 Trends |
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