从肺论治降低系统性红斑狼疮感染率的临床研究

目的 观察从肺论治降低系统性红斑狼疮（SLE）感染率及抗生素使用率的作用。方法 将110例SLE患者随机分为治疗组（55例）和对照组（55例），两组西医治疗方案相同。治疗组同时加用中药，病情活动期和静止期分别使用狼疮Ⅰ号及Ⅱ号协定方，对照组单纯使用西药治疗。结果 总有效率比较治疗组治疗3个月和6个月后分别为83．64％（46／55例）、87．27％（48／55例），对照组分别为78．18％（43／55例）、81．82％（45／55例），两组比较差异无显著性，治疗1年后两组疗效均有下降，治疗组为78．18％（43／55例），对照组为60．00％（33／55例），治疗组优于对照组（P〈0．05），治疗2年后治疗组为87．27％（48／55例），对照组为72．73％（40／55例）。两组比较差异无显著性。治疗2年期间感染率和抗生素使用率治疗组分别为23．6％（13／55例）、55．0％（11／20次），对照组分别为50．9％（28／55例）、100％（45／45次），治疗组均明显低于对照组（P〈0.01）。结论 从肺论治能够降低SLE感染率及抗生素的使用率。

Clinical Research on Effect of TCM Treatment Beginning with Fei in Treating Systemic Lupus Erythematosus for Reducing Incidence of Complicated Infection

OBJECTIVE: To observe the effect of TCM treatment beginning with Fei in reducing the incidence of complicated infection and the antibiotic utilization rate in patients with systemic lupus erythematosus (SLE). METHODS: One hundred and ten SLE patients were randomly assigned to 2 groups equally, the control group treated with the conventional Western medicinal treatment and the treated group treated with the same conventional treatment and SLE I formula (in active stage) or SLE II formula (in silent period) additionally. RESULTS: After 3-month and 6-month treatment, the total effective rate was 83.64% , 87.27% in the treated group, and 78.18%, 81.82% in the control group respectively, showing insignificant difference between the two groups. It lowered in both groups after 1-year treatment, however, which in the treated group (78.18%) was higher than that in the control group (60.00%, P < 0.05). But the difference became insignificant again after 2-year treatment, it being 87.27% in the treated group and 72.73% in the control group. The incidence of complicated infection and antibiotic utilization rate in the 2-year treatment was 23.6%, 55.0% respectively in the treated group, markedly lower than those (50.9% and 100%) in the control group respectively (P < 0.01). CONCLUSION: TCM treatment beginning with Fei could decrease the incidence of complicated infection and the antibiotic utilization rate in SLE patients.