阿米卡星的临床药动学与体内抗生素后效应

 目的：研究阿米卡星(AMK)在呼吸系统感染患者中的临床药动学、体内抗生素后效应(PAE)及两者间的关系。方法：采用荧光偏振免疫分析方法测定血清中AMK的浓度；采用吸光度法测定AMK对6株受试菌(3株标准质控菌，3株临床分离菌)的体内杭生素后效应。以3P87软件估算药动学参数。结果：AMK在7例呼吸系统感染患者体内的消除半衰期、清除率及药-时曲线(AUC)下面积分别，(3.10士0.61)h，(4.18士0.84)L·h^-1和(100.12士25.69)μg·h·ml^-1。AMK对6株受试菌具有明显的体内PAE，给药后12.5 h体内累加PAE值最大为32 h，平均为30 h；AUC与PAE呈良好的线性关系。结论：AMK的药动学及体内PAE研究表明，AMK 400 mg，静脉滴注，每日1次的给药方案是合理的。

Clinical pharmacokinetics and the post-antibiotic effect of amikacin in patients with respiratory tract infections

OBJECTIVE:Clinical pharmacokinetics,the post antibiotic effect (PAE) and the relationship between the former and the latter of amikacin (AMK) in patients with respiratory tract infections were studied. METHODS:Fluorescence polarization immunoassay method and the absorbance assay method were used to measure the concentrations of AMK in serum and the PAE of 6 strains tested bacteria (3 strains bacteria were standard quality control,3 strains were clinical isolated),respectively.Program 3P87 was used to account clinical pharmacokinetic parameters of patients. RESULTS:The elimination half life,clearance and area under concentration time curve (AUC) of AMK in 7 patients were (3.10±0.61) h,(4.18±0.84) L·h^-1and (100.12±25.69) μg·h·ml^-1,respectively.PAE of AMK against 6 strains tested bacteria was very significant.The maximum value and the average value of cumulative PAE at 12.5 h after administration were 32 h and 30 h,respectively.Relationship between AUC and PAE appeared to be linear. CONCLUSION:The results showed that the regimen of 400 mg amikacin,intravenously infusion,once daily is rational.