Species-specific evolution of repeated DNA sequences in great apes |
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Authors: | R. Toder F. Grützner T. Haaf E. Bausch |
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Affiliation: | (1) Institute of Human Genetics and Anthropology, University of Freiburg, Breisacher Straße 33, D-79106 Freiburg, Germany;(2) Present address: Currently at GeneScan Europe AG, Engesserstr. 4b, 79108 Freiburg, Germany;(3) Max Planck Institute for Molecular Genetics, Berlin, Germany |
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Abstract: | DNA sequencing reveals that the genomes of the human, gorilla and chimpanzee share more than 98% homology. Comparative chromosome painting and gene mapping have demonstrated that only a few rearrangements of a putative ancestral mammalian genome occurred during great ape and human evolution. However, interspecies representational difference analysis (RDA) of the gorilla between human and gorilla revealed gorilla-specific DNA sequences. Cloning and sequencing of gorilla-specific DNA sequences indicate that there are repetitive elements. Gorilla-specific DNA sequences were mapped by fluorescence in-situ hybridization (FISH) to the subcentromeric/centromeric regions of three pairs of gorilla submetacentric chromosomes. These sequences could represent either ancient sequences that got lost in other species, such as human and orang-utan, or, more likely, recent sequences which evolved or originated specifically in the gorilla genome. |
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Keywords: | genome evolution species-specific DNA sequences |
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