Repair problems in podocytes: wnt, notch, and glomerulosclerosis |
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| Authors: | Hideki Kato Katalin Susztak |
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| Affiliation: | Department of Medicine, Division of Nephrology, University of Teikyo, Tokyo, Japan. |
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| Abstract: | Wnt/Ctnnb1 and Notch signaling play key roles in kidney development and epithelial cell specification. Recent reports have suggested that these pathways are reactivated in response to injury and in different disease conditions. Studies using genetically modified animal models showed that sustained activation of Notch and Wnt signaling in podocytes are causally related to albuminuria and glomerulosclerosis development. Here, we discuss the role and regulation of Wnt/Ctnnb1 and Notch signaling in podocytes. |
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| Keywords: | Podocyte Notch signaling Wnt/beta-catenin signaling glomerulosclerosis |
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