轮状病毒肠炎患儿异型淋巴细胞和免疫球蛋白水平的变化分析

目的探讨轮状病毒（RV）肠炎患儿异型淋巴细胞数量及免疫球蛋白水平治疗前后变化的临床意义。方法分别检测50例RV肠炎患儿（肠炎患儿组）及30例健康小儿（健康对照组）治疗前后的血常规和异型淋巴细胞数量及血清免疫球蛋白水平。结果治疗前RV肠炎患儿组外周血异型淋巴细胞明显高于健康对照组（P〈0.01）,RV肠炎患儿血清免疫球蛋白IgA、IgM和IgG水平下降。治疗后RV肠炎患儿组外周血异型淋巴细胞低于治疗前（P〈0.05）,血清免疫球蛋白IgA、IgM和IgG水平上升甚至接近正常水平。结论 RV肠炎患儿治疗前后进行异型淋巴细胞数量及免疫球蛋白水平的检测有助于对病毒感染的判断及了解患儿的机体免疫功能状态和对疾病治疗的有效性,对RV肠炎患儿的治疗有指导意义。

Analysis on changes of abnormal lymphocytes and immunoglobulin level in children with rotavirus enteritis

Objective To investigate the significance of changes of abnormal lymphocytes and immunoglobulin level before and after treatment in children patients with rotavirus（RV） enteritis. Methods 50 cases of RV enteritis （enteritis group） and 30 healthy infants（healthy control group） were detected the blood routine,abnormal lympho- cyte count and serum immunoglobulin before and after treatment. Results The peripheral abnormal lymphocytes be- fore treatment in the enteritis group were significantly higher than those in the healthy control group（P〈0.01）, while serum immunoglobulin IgA, IgM and IgG levels in the enteritis group were decreased. Peripheral abnormal lym- phocytes after treatment in the enteritis group were lower than those before treatment（P〈0.05）, while serum immu- noglobulin IgA,IgM and IgG levels were risen,even close to the normal level. Conclusion Detecting abnormal lym- pbocytes and immunoglobulin levels before and after treatment in the children patients with RV enteritis is conducive to judge the viral infection, understand the immune function status and the effectiveness of treatment and has thet guidance significance to the treatment of RV enteritis.