| 浆细胞样树突状细胞前体细胞及其与疾病的研究进展 |
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| 引用本文： | 余艳,谢幸,吕卫国. 浆细胞样树突状细胞前体细胞及其与疾病的研究进展[J]. 免疫学杂志, 2006, 22(Z1): 60-63 |
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| 作者姓名： | 余艳 谢幸 吕卫国 |
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| 作者单位： | 浙江大学医学院附属妇产科医院中心实验室,杭州,310031 |
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| 摘 要： | 浆细胞样树突状细胞前体细胞(Pre-DC2)是属于淋巴系的一类细胞,自造血干细胞分化发育而来,表达独特表型的Pre-DC2在先天性和适应性免疫应答方面均发挥重要作用.作为体内主要的Ⅰ型干扰素(IFN)分泌细胞,Pre-DC2还具有诱导T细胞无反应性的能力.同时Pre-DC2还广泛参与病毒性疾病,自身免疫疾病,肿瘤等,本文就此作一综述.
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| 关 键 词： | 浆细胞样树突状细胞前体细胞 Ⅰ型干扰素 人类免疫缺陷病毒 自身免疫疾病 肿瘤 |
| 文章编号： | 1000-8861(2006)03(S)-0060-04 |
| 修稿时间： | 2006-04-04 |
Plasmacytoid dendritic cell precursors and human diseases |
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| YU Yan. Plasmacytoid dendritic cell precursors and human diseases[J]. Immunological Journal, 2006, 22(Z1): 60-63 |
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| Authors: | YU Yan |
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| Abstract: | Plasmacytoid dendritic cell precursors(Pre-DC2) are of lymphoid origin,developing from hematopoietic stem cells(HSC).Pre-DC2 with specific phenotypic characteristics plays an important role in both innate immune responses and adaptive immune responses.As professional type 1 interferon-producing cells,Pre-DC2 have a capacity to induce an anergic state in human T cell lines.Thus, Pre-DC2 involved in viral infectious diseases,autoimmune diseases,and tumor.Here,we review the functions of Pre-DC2 and the relations of Pre-DC2 with human diseases. |
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| Keywords: | Plasmacytoid dendritic cell precursors Type 1 interferon HIV Autoimmune diseases Tumor |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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