泼尼松在肉芽肿性小叶性乳腺炎中的应用

目的探讨肉芽肿性小叶性乳腺炎临床病理特征及泼尼松治疗的临床疗效。方法对14例肉芽肿性小叶性乳腺炎患者临床病理特征及预后进行回顾性分析。结果 85.7%的患者在产后1～4年发病,平均随访时间11.7个月,临床最常见的症状是乳腺肿块及疼痛,影像学表现为非特异性改变,泼尼松治疗2周后缓解率为92.9%,54.5%患者停药后获得治愈并最终免除手术,未观察到患者复发。结论肉芽肿性小叶性乳腺炎好发于育龄期经产妇女,泼尼松治疗可使大部分患者免除手术获得治愈。

Therapeutic effect of prednisone in granulomatous lobular mastitis

Objective To investigate the clinicopathological features of granulomatous lobular mastitis and the therapeutic effect of prednisone.Methods Clinicopathological features and prognosis were analyzed retrospectively in 14 women with granulomatous lobular mastitis.Results 85.7%of patients were diagnosed 1-4 years after childbirth(mean age 30 years).The mean follow-up were 11.7 months.The most common symptoms were breast mass and pain.No specific radiological feature was found.The remission rate of prednisone was 92.9%after 2 weeks of treatment,54.5%patients exempt from surgery were cured by prednisone alone.No recurrence was observed.Conclusions Granulomatous lobular mastitis usually affects parous women of child-bearing age.Pathological evaluation can provide an exact diagnosis.Majority of patients received single prednisone treatment would receive a curative effect without surgery.