Chemokine receptors associated with immunity within and outside the central nervous system in early relapsing-remitting multiple sclerosis |
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Authors: | Wang Hui-Yun Matsui Makoto Araya Shin-ichi Onai Nobuyuki Matsushima Kouji Saida Takahiko |
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Institution: | Department of Neurology and Clinical Research Center, Center for Neurological Diseases, Utano National Hospital, Ukyo, Kyoto 616-8255, Japan. |
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Abstract: | Thirty-four patients with early relapsing-remitting multiple sclerosis (RRMS) were studied to clarify the differences in chemokine receptor usage by blood and cerebrospinal fluid (CSF) lymphocytes relevant to the pathogenesis of MS. A total of 45 examinations (33 active and 12 inactive stages) revealed that circulating CD4+CXCR3+ T helper 1 (Th1) cells were increased in active MS patients and correlated with the number of gadolinium-enhanced lesions on magnetic resonance (MR) images. In contrast, CSF samples obtained during active stages were characterized by a decrease in the percentage of CD8+CXCR3+ T cells, which was inversely correlated with CSF cell count and intra-blood-brain barrier (BBB) IgG production. |
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