Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals |
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Authors: | A J Anderson A L Harvey |
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Affiliation: | Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, U.K. |
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Abstract: | Release of acetylcholine at the neuromuscular junctions of skeletal muscle is not sensitive to organic Ca2+ channel blockers. However, in mouse motor nerve endings, extracellular recording reveals that a verapamil-sensitive Ca2+ current can be induced after block of K+ channels. Recordings of extracellular action potentials from inside the perineural sheaths of nerves innervating mouse triangularis sterni muscles reveal that this verapamil-sensitive current is not blocked by omega-conotoxin, and hence, it does not involve channels similar to the L-channels of neuronal cell bodies. |
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