电针对全膝关节置换术后辅助镇痛的临床疗效观察

Electroacupuncture on adjuvant analgesia after total knee arthroplasty:A randomized controlled trail

ObjectiveTo observe the clinical effect of electroacupuncture (EA) for alleviating pain after total knee arthroplasty (TKA) in the patients with the end-stage knee osteoarthritis and its mechanism.MethodsA total of 80 subjects with unilateral TKA were divided into a celecox group (40 cases) and an EA combination group, using random number table in clinical trial. In the celecox group, after operation, celecox tablets were taken orally for analgesia. In the EA combination group, on the base of oral administration of celecox tablets, on the day of operation, EA was exerted on the affected limb, with disperse-dense wave, 2 Hz/100 Hz in frequency, 3 mA in current intensity, once daily, 30 min each time, consecutively for 3 days. On the day after operation, Wàiqiū (外丘GB36), Jīnmén (金门BL63), Nèimádi?n (内麻点EX-LE29) and Zúsānl? (足三里ST36) were selected in EA. 24 h after removing the drainage tube, Liángqiū (梁丘ST34), Xuèh?i (血海SP10), Dìjī (地机SP8) and Yánglíngquán (阳陵泉GB34) were used. Separately, the operation time, blood loss, the pain VAS score before operation, the pain VAS scores after 24, 48 and 72 h of treatment and Self-rating scale of sleep (SRSS) score, as well as the stress factors, i.e. IL-6, IL-10 and TNF-α in serum were recorded and determined in the subjects of two groups.ResultsBefore treatment, the operation time and blood loss were not different between two groups (both P > 0.05). 24, 48 and 72 h after operation, the visual analogue scale (VAS) scores in the celecox group were all higher than those in the EA combination group (all P < 0.05). After treatment, SRSS score in the EA combination group was lower than that in the celecox group (P < 0.05). The expressions of IL-6 and TNF-α were reduced gradually in the two groups (all P < 0.05) and the values in the EA combination group were lower than the celecox group (P < 0.05). IL-10 was increased gradually (P < 0.05) and the value in the EA combination group was higher than the celecox group (P < 0.05).ConclusionElectroacupuncture effectively alleviates pain induced by TKA and the curative effect is definite. This therapy contributes to accelerating rehabilitation and its effect mechanism may be related to promoting the release of anti-inflammatory factor, IL-10 and inhibiting the expressions of inflammatory factors, IL-6 and TNF-α.