测定胸液中D-二聚体含量的临床意义

应用酶联免疫吸附法测定 4 5例不同原因所致胸腔积液的 D 二聚体 (D D)含量。结果示 ,结核性胸液与脓性胸液中D D含量明显高于癌性胸液 (P <0 .0 1;P <0 .0 5 ) ,且胸液中D D含量与乳酸脱氢酶含量呈正相关 (r=0 .4 168,P <0 .0 1)。结果提示 ,结核性及脓性胸液纤溶活性较恶性胸液高 ,检测胸液中D D含量可反映胸膜炎症反应的程度 ,有助于临床上对胸腔积液的鉴别。

Detection of D-dimer in pleural effusion

The content of D dimer in pleural fluid of different causes was examined by the ELISA method in 45 patients. The results were that the contents of D dimer in both tuberculous and empyema pleural effusions were significantly higher than in malignant pleural effusion(P<0.01;P<0.05). D dimer was positively correlated with lactic dehydrogenase (LDH) in pleural fluid (r=0.4168,P<0.01). The results suggest that fibrinolytic activities in tuberculous and empyema pleural effusion are much higher than in malignant pleural effusion. The detection of D dimer in pleural fluid may reflect the extent of pleural inflammation and be helpful in the differential diagnosis of pleural effusion.