Acute and Chronic Phases of Toxoplasma gondii Infection in Mice Modulate the Host Immune Responses |
| |
| Authors: | T. D. Nguyen G. Bigaignon J. Van Broeck M. Vercammen T. N. Nguyen M. Delmee M. Turneer S. F. Wolf J. P. Coutelier |
| |
| Affiliation: | Microbiology Unit, Cliniques Universitaires Saint-Luc,1. and Experimental Medicine Unit, ICP, Catholic University of Louvain,2. 1200 Brussels, and Institut Pasteur, 1180 Brussels,3. Belgium, and Genetics Institute, Inc., Cambridge, Massachusetts 021404. |
| |
| Abstract: | Murine antibody responses to soluble proteins are generally restricted to the immunoglobulin G1 (IgG1) isotype. When mice were infected with Toxoplasma gondii Beverley and concomitantly immunized with a soluble unrelated protein antigen, a modification in the isotypic distribution of antibodies directed against this nonparasite antigen was observed, with a preferential production of IgG2a. Interestingly, when mice were immunized with a soluble protein antigen during the chronic phase (day 40) of infection with T. gondii Beverley, a similar modification in the isotypic distribution of antiprotein antibodies was observed. |
| |
| Keywords: | |
|
|
