| Gastrointestinal migrating motor complex during early stage of cholesterol gallstone formation in guinea pigs |
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| 作者姓名： | Wang Ling Bai Wenyuan Ma Yongzhi Gu Yong |
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| 作者单位： | [1]Shan ＇xi Provincial Corps Hospital, Chinese People’s Armed Police Force, Xi ＇an 710054, China [2]Department of Gastrointestinal Internal Medicine, the 2nd Hospital of Hebei Medical University, Shijiazhuang 050017, China |
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| 摘 要： | Objective： To determine the changes of gastrointestinal migrating motor complex （MMC） during the early stage of cholesterol gallstone formation. Methods：Totally 45 healthy adult guinea pigs were randomly and equally divided into 3 groups, that is, normal control, group B （1% cholesterol diet for 2 weeks） and group C （1% cholesterol diet for 4 weeks）. Three pairs of silver electrodes were inserted into the gastric antrum, duodenum and jejunum of every animal respectively. Record of gastrointestinal MMC of these guinea pigs were recorded and analyzed. Gallbladder bile was taken to detect the formation of cholesterol gallstone. Results： There were only 29 guinea pigs living. The MMC cycle time and the duration of phase Ⅱ were prolonged significantly and gradually compared with the control group （P〈0.01）, but the duration of phase Ⅲ became significantly and gradually shorter. Conclusion： During the early stage of cholesterol gallstone formation, the MMC cycle time and the duration of phase Ⅱ are prolonged and the duration of phase Ⅲ is shortened.
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| 关 键 词： | 胆固醇 几内亚猪 动物实验 胆结石 |
| 收稿时间： | 2007-10-20 |
| 修稿时间： | 2008-01-09 |
Gastrointestinal migrating motor complex during early stage of cholesterol gallstone formation in guinea pigs |
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| Wang Ling Bai Wenyuan Ma Yongzhi Gu Yong.Gastrointestinal migrating motor complex during early stage of cholesterol gallstone formation in guinea pigs[J].Journal of Medical Colleges of PLA(China),2008,23(1):9-14. |
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| Authors: | Wang Ling Bai Wenyuan Ma Yongzhi Gu Yong |
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| Institution: | 1. Shan''xi Provincial Corps Hospital, Chinese People''s Armed Police Force, Xi''an 710054, China;2. Department of Gastrointestinal Internal Medicine, the 2nd Hospital of Hebei Medical University, Shijiazhuang 050017, China;1. Department of Biotechnology, Daegu University, Kyongsan, Kyongbok 712-714, Republic of Korea;2. Metalloenzyme Research Group and School of Biological Sciences, Chung-Ang University, Anseong 456-756, Republic of Korea;1. Higashi Clinic, 589-1 Higashi-Honjou, Minabe-Cho, Hidaka-Gun, Wakayama Prefecture 645-0021, Japan;2. Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;3. Yaotome Ekimae Clinic of Internal Medicine and Pediatrics, 1-3-26 Yaotome-Chuo, Izumi-ku, Sendai 981-3135, Japan;4. South Miyagi Medical Center, 38-1 Aza-nishi, Ohgawara, Shibata-gun, Miyagi Prefecture 989-1253, Japan;1. Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Hong Kong, China;3. CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China;4. Department of Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, China;5. Department of Biochemistry and Environment Science, Yi Li Normal University, Yining, China;1. School of Automotive Studies, Tongji University, Shanghai 200092, China;2. Department of Aeronautical and Automotive Engineering, Loughborough University, Loughborough LE11 3TU, UK |
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| Abstract: | Objective: To determine the changes of gastrointestinal migrating motor complex (MMC) during the early stage of cholesterol gallstone formation. Methods: Totally 45 healthy adult guinea pigs were randomly and equally divided into 3 groups, that is, normal control, group B (1% cholesterol diet for 2 weeks) and group C (1% cholesterol diet for 4 weeks). Three pairs of silver electrodes were inserted into the gastric antrum, duodenum and jejunum of every animal respectively. Record of gastrointestinal MMC of these guinea pigs were recorded and analyzed.Gallbladder bile was taken to detect the formation of cholesterol gallstone. Results: There were only 29 guineapigs living. The MMC cycle time and the duration of phase Ⅱ were prolonged significantly and gradually compared with the control group (P<0.01), but the duration of phase Ⅲ became significantly and gradually shorter. Conclusion:During the early stage of cholesterol gallstone formation, the MMC cycle time and the duration of phase Ⅱ are prolonged and the duration of phase Ⅲ is shortened |
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| Keywords: | High cholesterol diet Interdigestive stage Migrating motor complex |
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