小细胞肺癌预防性脑照射的临床研究

目的 探讨性全脑照射（ＰＣＩ）对局限期小细胞肺癌（ＳＣＬＣ）脑转移率和生存率的影响。方法 １９９０年１月～１９９５年１２月间，５１例经化疗加放疗后完全缓解的局限期ＳＣＬＣ患者被承机分为脑照射组（２６例）和对照组（２５例）。脑照射组患者接受ＰＣＩ２５．２～３０．６Ｇｙ。结果 脑照射组患者的脑转移率为３．８％，明显你芋对照组的２８．０％（Ｐ〈０．０５）。脑照射组患者和，１，２，３年生存率分别为８４．６

Clinical study of prophylactic cranial irradiation for small-cell lung cancer

OBJECTIVE: To study the influence of prophylactic cranial irradiation (PCI) on survival and brain metastases in patients with limited small-cell lung cancer (SCLC). METHODS: Fiftyone patients with limited SCLC under complete remission after chemoradiotherapy were randomly divided into prophylactic cranial irradiation (PCI) group (n = 26) and control group (n = 25). Patients in PCI group received irradiation at a dose of 25.2-30.6 Gy. Survival rates were analyzed and compared by life table and Long-Rank, incidence of cranial metastases by chi 2 test. RESULTS: The clinical features of patients such as age, sex, effect of treatment before PCI were similar between the two groups. The incidence of cranial metastases was 3.8% in PCI group in contrast to 28% in the control group (P < 0.05). The 1, 2, 3-year survival rate was 84.6%, 73.1%, 42.3% respectively in PCI group and 72%, 40%, 32% respectively in the control group. The differences between the two groups of petients were statistically insignificant. No serious sequela was observed in patients receiving PCI. CONCLUSION: PCI decreases the incidence of cranial metastases for patients with limited SCLC following complete response to chemoradiotherapy, but it does not improve survival.