Total homocyst(e)ine in plasma and amniotic fluid of pregnant women |
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| Authors: | S S Kang P W Wong J M Zhou H Y Cook |
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| Institution: | 1. Department of Pediatrics, Section of Genetics, Rush Medical College Chicago, USA.;2. Rush-Presbyterian-St Luke''s Medical Center, Chicago, USA.;1. University of Veterinary Medicine, Department of Obstetrics and Reproduction, István str 2., H-1078 Budapest, Hungary;2. Department of Anatomy, University of Pecs Medical School, MTA-PTE PACAP Research Team, Szigeti str 12., H-7624 Pécs, Hungary;1. Indiana University School of Medicine, Department of Pharmacology and Toxicology, USA;2. Indiana University School of Medicine, Stark Neuroscience Research Institute, USA;3. Indiana University School of Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, USA;1. Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, TX;2. Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX;1. Department of Cardiology, First Affiliated Hospital, Shantou University Medical College, Shantou, China;2. Cardiovascular Research Center, Shantou University Medical College, Shantou, China;3. The Central Laboratory, Shantou University Medical College, Shantou, China;1. Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, 980-8578, Japan;2. Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (AMED-CREST), Tokyo, 100-0004, Japan;3. Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology (PRESTO), Saitama, 332-0012, Japan |
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| Abstract: | Total homocyst(e)ine was determined by the quantitation of protein-bound homocyst(e)ine in the stored plasma and amniotic fluid from 25 pregnant women and in the stored plasma from 17 nonpregnant women. The mean +/- SE of plasma total homocyst(e)ine was 29.8 +/- 2.4 nmol/g protein in pregnant women and 52.4 +/- 3.8 nmol/g protein in nonpregnant women. In contrast, the mean +/- SE of total homocyst(e)ine in amniotic fluid obtained at 16 weeks of gestation was 36.3 +/- 2.9 nmol/g protein. There was a statistically significant difference in the plasma total homocyst(e)ine concentrations from pregnant and nonpregnant women (P less than 0.01). Similarly, there was also a statistically significant difference between plasma total homocyst(e)ine from nonpregnant women and amniotic fluid total homocyst(e)ine (P less than 0.01). These observations suggested that the metabolism of homocysteine to cysteine was more efficient in pregnant women. In addition, the concentrations of total homocyst(e)ine in amniotic fluids were within narrow limits in normal pregnancies. Hence, total homocyst(e)ine concentration might be very valuable as a rapid assessment of fetuses for congenital defects of homocysteine metabolism. |
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