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Serotonin as a neurotransmitter in cerebral arteries |
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| Authors: | S. G. Griffith J. Lincoln G. Burnstock |
| Affiliation: | Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy |
| Abstract: | Evidence is presented for the existence of serotoninergic nerves in rabbit verterbral artery: the neurogenic vasoconstrictor response in isolated vessels was resistant to adrenoceptor and cholinoceptor blockede but was blocked by ketanserin, a serotonin (5-HT) antagonist; vertebral arteries contained high levels of 5-HT (over 0.5 μg/g wet weight) and its metabolite, 5-hydroxyindoleacetic acid (over 0.6 μg/g wet weight); and a 5-HT-immunoreactive nerve plexus was demonstrated. The possible role of these nerves is discussed. |
| Keywords: | rabbit vertebral artery 5-hydroxytryptamine non-adrenergic, non-cholinergic nerves serotoninergic nerves cerebral blood vessels perivascular nerves migraine |
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